Substantial evidence for the rhododendrol-induced generation of hydroxyl radicals that causes melanocyte cytotoxicity and induces chemical leukoderma [PDF]
Journal of Dermatological Science, 2018 Rhododendrol (4-(4-hydroxyphenyl)-2-butanol) has been used as a lightening/whitening cosmetic but was recently reported to induce leukoderma. Although rhododendrol has been shown to be transformed by tyrosinase to hydroxyl-rhododendrol, which is cytotoxic to melanocytes, its detailed mechanism of action including the involvement of reactive oxygen ...
Yu Gabe +5 more
openaire +2 more sources
Scientifica, Volume 2025, Issue 1, 2025.Apricot kernels contain amygdalin, a cyanogenic glycoside that degrades to cyanide upon chewing or crushing, posing a potential toxicity risk to humans. The present study aimed to determine the phenolic compounds and to evaluate the subacute and acute toxicity of the aqueous extract of bitter apricot kernels (BAKs) in Swiss albino mice.
Mohamed Amine El-Hajjaji +7 more
wiley +1 more source
Pigmentary Disorders: Elucidation of Pathogenesis for Recovery of Health and Wellness
The Journal of Dermatology, Volume 53, Issue 2, Page 167-168, February 2026.
Naoki Oiso
wiley +1 more source
Tyrosinase Inhibition and Antimelanogenic Effects of Resorcinol‐Containing Compounds
ChemMedChem, Volume 19, Issue 23, December 2, 2024.Resorcinol‐based compounds stand out as key inhibitors of tyrosinases (TYR) owing to their phenolic group's interaction with the dicopper centre and their ability to resist TYR‐mediated oxidation. While some well‐known examples are employed in dermatocosmetics and skin‐whitening products, this review covers the broader diversity of scaffolds, including
Morane Beaumet +3 more
wiley +1 more source
Chemical leukoderma to hydroquinone: A rare phenomenon
Pigment InternationalChemical leukoderma is characterized by the development of acquired vitiligo-like hypo- to depigmented macules due to persistent or negligent chemical use. Sulfhydryl and potent phenol/catechol compounds are included in the etiology. The incidence of chemical leukoderma has been increasing in developing countries like India due to inadequate monitoring
Mohd Shurjeel Ul Islam +3 more
openaire +1 more source
Food Science &Nutrition, Volume 12, Issue 7, Page 4989-5006, July 2024.In recent decades, green synthesis has been attested as the most suitable technique for synthesizing metal nanoparticles. C. angustifolia and P. vera extract possess a variety of bioactive compounds with various biological activities and are therapeutically effective. C. angustifolia and P.
Saba Irshad +7 more
wiley +1 more source
Genetic insights into Tietz albinism‐deafness syndrome: A new dominant‐negative mutation in MITF
Pigment Cell &Melanoma Research, Volume 37, Issue 4, Page 430-437, July 2024.We uncovered a previously unreported c.637G>C (p.Glu213Gln) mutation in the MITF in a patient with Tietz albinism‐deafness syndrome (TADS), elucidating its genetic and clinical significance. The combined results from histopathological examination, transmission electron microscopy analysis, and melanin quantification underscored the substantial ...
Kohei Yamamoto +8 more
wiley +1 more source
Chemical Leukoderma Associated with Methylphenidate Transdermal System: Data From the US Food and Drug Administration Adverse Event Reporting System. [PDF]
J Pediatr, 2017 Cheng C +4 more
europepmc +1 more source
Tulobuterol Patch (Hokunalin® Tape)-Induced Leukoderma: A Case Report. [PDF]
Ann Dermatol, 2023 Song A, Yoo DS, Lee SE.
europepmc +1 more source
Expert opinion about laser and intense pulsed light (IPL)-induced leukoderma or vitiligo: a cross-sectional survey study. [PDF]
Arch Dermatol Res, 2023 Post NF +17 more
europepmc +1 more source