Results 111 to 120 of about 1,570,001 (303)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Nanofibrous Porous Organic Polymers and Their Derivatives: From Synthesis to Applications

Advanced Science
Engineering porous organic polymers (POPs) into 1D morphology holds significant promise for diverse applications due to their exceptional processability and increased surface contact for enhanced interactions with guest molecules.
Chen Yang, Kexiang Wang, Wei Lyu, He Liu, Jiaqiang Li, Yue Wang, Ruyu Jiang, Jiayin Yuan, Yaozu Liao   +8 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A Theoretical Simulation of Deformed Carbon Nanotubes with Adsorbed Metal Atoms: Enhanced Reactivity by Deformation

, 2010
First-principles simulations were performed to investigate reaction of carbon nanotubes with adsorbed metal atoms. Mechanical modification of their structures enhances chemical reactivity of carbon nanotubes.
Amelinckx, Carroll, Chandra, Charlier, Charlier, Conversano, David, Duong, Durgun, Ebbsesen, Fujita, Giannozzi, Hohenberg, Horner, Iijima, Inoue, Jiang, Jin-Phillipp, Kim, Kohn, Koichi Kusakabe, Li, Martel, Meunier, Miyake, Naoki Hosoya, Nardelli, Nardelli, Novoselov, Perdew, Perdew, Picozzi, Pozrikidis, S. Uma Maheswari, Seo, Stone, Suenaga, Tans, Tekleab, Terrones, Thess, Vanderbilt, Wako, Wong, Yakobson, Yang, Yang, Yang, Zhang, Zhou, Zhuang   +50 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Thresholds, long delays and stability from generalized allosteric effect in protein networks

, 2006
Post-transductional modifications tune the functions of proteins and regulate the collective dynamics of biochemical networks that determine how cells respond to environmental signals. For example, protein phosphorylation and nitrosylation are well-known
Alessio Del Fabbro, Bergeland, Chiara Dalla Pellegrina, Choi, Clare, Cohen, Cohen, Dong, D’Orsogna, Edoardo Milotti, Ezhevsky, Gunawardena, Henry, Hill, Holcik, Koshland, Mannick, Merks, Monod, Qian, Roberto Chignola, Schnell, Seville, Shacter, Weiss, Yang   +25 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Suppressants for lowering propellant binder burning rate [PDF]

, 1972
Addition of boron compound to lower burning rate of solid propellant binder is reported. Chemical reactions involved in propellant binder modification are described.
Thompson, W. W.
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source