Results 211 to 220 of about 650,908 (266)
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Chemical Modification of siRNA
Current Protocols in Nucleic Acid Chemistry, 2009AbstractThe ability to manipulate the RNA interference (RNAi) machinery to specifically silence the expression of target genes could be a powerful therapeutic strategy. Since the discovery that RNAi can be triggered in mammalian cells by short double‐stranded RNAs (small interfering RNA, siRNA), there has been a tremendous push by researchers, from ...
Deleavey, Glen F. +2 more
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Chemical modification of neamine
Carbohydrate Research, 1977The aminocyclitol antibiotic neamine has been modified chemically by removing one or two hydroxyl groups from the 2-deoxystreptamine moiety to give 5- and 6- deoxyneamines (5 and 10), as well as 5,6-dideoxyneamine (15). Their antimicrobial activities were determined against several microorganisms, including kanamycin-resistant strains.
T, Suami +3 more
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THE CHEMICAL MODIFICATION OF CHYMOTRYPSIN
Canadian Journal of Biochemistry, 1964Chemical modification of chymotrypsin has led to the identification of several amino acid side-chains which are probably constituents of the active site of the enzyme. A single seryl and a single histidyl residue appear to cooperate in catalyzing the bond-breaking process while one or more tryptophanyl residues may be involved in the specific binding ...
G H, DIXON, H, SCHACHTER
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Heterogeneity of chemical modifications on RNA
Biophysical Reviews, 2023The chemical modifications of RNAs broadly impact almost all cellular events and influence various diseases. The rapid advance of sequencing and other technologies opened the door to global methods for profiling all RNA modifications, namely the "epitranscriptome." The mapping of epitranscriptomes in different cells and tissues unveiled that RNA ...
W. S. Sho Goh, Yi Kuang
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Chemical Modification of Rhodanese with Sulphite
Free Radical Research Communications, 1991The essential sulphydryl group of bovine liver rhodanese (thiosulphate: cyanide sulphurtrasferase, E.C. 2.8.1.1.) is modified by sulphite produced during the enzymatic reaction or added to the fully active enzyme. The enzyme treated with labelled reagent incorporates 1 equivalent of SO3(2-) and loses one -SH group with the formation of a S-sulphonate ...
BERNI R +3 more
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Journal of Macromolecular Science: Part A - Chemistry, 1977
Abstract Despite the fact that polyvinyl chloride) (PVC) has occupied the most important position among general-purpose plastics, its industrial applications are limited due to its inferior thermal stability and mechanical properties. Many studies have been conducted to remedy these disadvantages.
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Abstract Despite the fact that polyvinyl chloride) (PVC) has occupied the most important position among general-purpose plastics, its industrial applications are limited due to its inferior thermal stability and mechanical properties. Many studies have been conducted to remedy these disadvantages.
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Chemical methods for modification of proteins
Organic & Biomolecular Chemistry, 2020The field of protein bioconjugation draws attention from stakeholders in chemistry, biology, and medicine. This review provides an overview of the present status, challenges, and opportunities for organic chemists.
Neelesh C. Reddy +3 more
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Chemical Modification Interference
Cold Spring Harbor Protocols, 2015Chemical modification interference is a powerful method for surveying an entire RNA molecule to identify functionally important chemical groups. The basic idea is to generate a pool of end-labeled RNAs wherein each RNA molecule is chemically modified (e.g., by diethyl pyrocarbonate [DEPC], hydrazine, dimethyl sulfate, CMCT, or kethoxal) at a different ...
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Chemical modification of carbon nanotubes
Mendeleev Communications, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Valery N. Khabashesku +1 more
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1997
Abstract Chemical modification is one of the most useful methods of identifying the functional groups of a protein. Whether or not the various types of amino acid side chains are involved in a protein’s function can be determined readily by whether or not chemical modification of that type of amino acid affects the function.
Taiji Imoto, Hidenori Yamada
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Abstract Chemical modification is one of the most useful methods of identifying the functional groups of a protein. Whether or not the various types of amino acid side chains are involved in a protein’s function can be determined readily by whether or not chemical modification of that type of amino acid affects the function.
Taiji Imoto, Hidenori Yamada
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