Results 221 to 230 of about 650,908 (266)
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Chemical modification of silica gels
Journal of Sol-Gel Science and Technology, 1997Highly porous pure and polyethyleneglycol (PEG)-doped silica gels have been prepared from tetraethyl orthosilicate (TEOS) in ethanol using NH4OH base-catalysis. Addition of PEG to the SiO2-systemincreases the average particle size and most frequent pore diameter of the resultant gels while their total surface areadecreases.
M.S.W. Vong, N. Bazin, P.A. Sermon
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Chemical Modification of Proteins
2003The two most widely used applications for chemical modification are in primary structure analysis and in the identification of essential groups involved in the binding and catalytic sites of proteins. The methods discussed here are those used frequently in primary structure analysis.
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Chemical Modification of Alpha Crystallin
Experimental Eye Research, 1993Calf lens alpha-crystallin was isolated and the lysine residues were extensively modified with a variety of chemical agents. The effect of these modifications on elastase inhibitor activity, apparent molecular size, antibody reactivity and solubility were determined. The addition of either a methyl group or a threose residue did not alter the charge on
B J, Ortwerth +3 more
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THE CHEMICAL MODIFICATION OF ENZYMATIC SPECIFICITY
Annual Review of Biochemistry, 1985The chemical modification of enzymes has played and will continue to play an important role in probing the mechanism of enzyme activity. This technique can be utilized for identification of those individual amino acid residues responsible for the catalytic properties of the entire protein.
E T, Kaiser, D S, Lawrence, S E, Rokita
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Reading Chemical Modifications in the Transcriptome
Journal of Molecular Biology, 2020Diverse chemical modifications have been identified in the transcriptome, leading to the emerging field of epitranscriptomics. In eukaryotic mRNA, the 5' cap and 3' poly(A) tail play important roles in regulation, and multiple internal modifications have also been revealed to participate in RNA metabolism.
Jinghui Song, Chengqi Yi
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Acid glycosaminoglycans and their chemical modification
Russian Journal of Bioorganic Chemistry, 2008The modem state of chemical modification of hyaluronic acid, chondroitin sulfates, and heparin is considered, and the possible application of modified glycosaminoglycans as potential drugs is discussed.
I Iu, Ponedel'kina +2 more
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The Chemical Modification of Nucleic Acids
1969Publisher Summary This chapter describes chemical modification of nucleic acids. Modification of the units of polymer chains by reaction with chemical agents is one of the promising methods for studying the structure and function of biopolymers, particularly polynucleotides.
N K, Kochetkov, E I, Budowsky
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Implications of the chemical modification of chymotrypsin
Biochemical and Biophysical Research Communications, 1973Abstract The short N-terminal chain of δ-chymotrypsin, a two-chain member of the chymotrypsin family, was removed by reduction. The residual reduced major chain exhibited significant enzymic activity after refolding at low pH had occurred, and most of the native activity was regained upon subsequent oxidation.
S M, Grey, G R, Nurse, L, Visser
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Chemical Modification of Heparin and Heparosan
2014Heparin is a potent clinically used anticoagulant. It is a heterogeneous mixture of polymers that contain a variety of sulfation patterns. However, only 3-O sulfonated heparin pentasaccharide units have been proven to bind to antithrombin and elicit an anticoagulant response. Heparins with other sulfation patterns are able to bind to a variety of other
Karthik, Raman +2 more
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