Results 201 to 210 of about 650,908 (266)

Chemical Modification of Acrylonitrile-Divinylbenzene Polymer Supports with Aminophosphonate Groups and Their Antibacterial Activity Testing. [PDF]

Molecules
Nichita I, Lupa L, Visa A, Dragan ES, Dinu MV, Popa A.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Improved Mechanical and Physical Properties of Epoxy Acrylate Oligomers by Chemical Modification for the Effective Encapsulation of the Triple-Cation Perovskite Solar Cells. [PDF]

ACS Omega
Ercan BT, Mutlu A, Gultekin SS, Gultekin B, Dincalp H, Zafer C.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Chemical Modification of Nanocrystalline Cellulose for Manufacturing of Osteoconductive Composite Materials. [PDF]

Polymers (Basel)
Solomakha O, Stepanova M, Dobrodumov A, Gofman I, Nashchekina Y, Nashchekin A, Korzhikova-Vlakh E.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Effects of Ring Opening and Chemical Modification on the Properties of Dry and Moist Cellulose─Predictions with Molecular Dynamics Simulations. [PDF]

Biomacromolecules
Elf P, Larsson PA, Larsson A, Wågberg L, Hedenqvist MS, Nilsson F.   +5 more
europepmc   +1 more source

Unveiling sequence-agnostic mixed-chemical modification patterns for splice-switching oligonucleotides using the NATURA platform. [PDF]

Mol Ther Nucleic Acids
Tabaglio T, Agarwal T, Cher WY, Ow JR, Chew AK, Sun PYQ, Reddy Gurrampati RS, Lu H, Naidu P, Ng HK, Le Guezennec X, Ng SY, Lakshmanan M, Guccione E, Wee KB.   +14 more
europepmc   +1 more source

Advancing Sustainability: Geraniol-Enhanced Waterborne Acrylic Pressure-Sensitive Adhesives without Chemical Modification. [PDF]

Materials (Basel)
Di Lorenzo L, Bordignon S, Chierotti MR, Alfeo IA, Antosik AK, Brunella V.   +5 more
europepmc   +1 more source

Impact of the chemical modification of tRNAs anticodon loop on the variability and evolution of codon usage in proteobacteria. [PDF]

Front Microbiol
Delgado S, Armijo Á, Bravo V, Orellana O, Salazar JC, Katz A.   +5 more
europepmc   +1 more source