Results 71 to 80 of about 226,475 (267)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Mean Drop Diameter in a Rotating Sieved Disc Contactor

International Journal of Technology, 2015
A correlation has been proposed for mean drop diameter in a Rotating Sieved Disc Contactor (RSDC) considering drops break up, as well as drops coalescence with static holdup in the case of no mass transfer.
Fatemeh Behzad, Hossein Bahmanyar, Hoda Molavi, Setareh Manafi   +3 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Langmuir Monolayer Studies of Phosphatidylcholine Membranes with Naproxen on the Polysaccharide Subphase

Molecules
Natural polysaccharides are biocompatible and biodegradable; therefore, they can be widely used in drug delivery, tissue engineering and wound healing. In this context, the interactions between polysaccharides, drugs and biological membranes are of great
Małgorzata Jurak, Katarzyna Pastuszak, Agnieszka Ewa Wiącek   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

One-step fabrication of PVDF Janus membranes by template-induced texturing and Janus nanosheet self-orientation for membrane distillation

Results in Engineering
Membrane distillation (MD) is a promising thermal desalination technology; however, achieving high permeate flux, excellent wetting resistance, and long-term operational stability simultaneously remains challenging, often requiring multistep surface ...
Kobra Bagheri, Mojtaba Shariaty-Niassar, Javad Karimi Sabet, Abolfazl Dastbaz, Mahdi Akbari   +4 more
doaj   +1 more source

I. A chemical inquiry into the phenomena of human respiration [PDF]

Philosophical Transactions of the Royal Society of London. (B.), 1890
Abstract A love of mountaineering is a natural inducement to inquire into the influence of altitude on the phenomena of respiration, and I began giving attention to that subject in 1875; my first results, however, were not communicated to the Royal Society till the month of March, 1878. In September, 1877, Dr. A.
openaire   +2 more sources

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source