Results 31 to 40 of about 1,184,807 (285)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Protein Structure Determination Using Chemical Shifts [PDF]
arXiv, 2014 In this PhD thesis, a novel method to determine protein structures using chemical shifts is presented.
arxiv
Ordering chemical graphs by Sombor indices and its applications [PDF]
arXiv, 2021 Topological indices are a class of numerical invariants that predict certain physical and chemical properties of molecules. Recently, two novel topological indices, named as Sombor index and reduced Sombor index, were introduced by Gutman, defined as $$SO(G)=\sum_{uv\in E(G)}\sqrt{d_{G}^{2}(u)+d_{G}^{2}(v)},$$ $$SO_{red}(G)=\sum_{uv\in E(G)}\sqrt{(d_{G}
arxiv
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
Chemical physics of materials [PDF]
The Journal of Chemical Physics, 2020 Erinn C. Brigham +7 more
openaire +4 more sources
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Amazing variational approach to chemical reactions [PDF]
arXiv, 2009 In this letter we analyse an amazing variational approach to chemical reactions. Our results clearly show that the variational expressions are unsuitable for the analysis of empirical data obtained from chemical reactions.
arxiv
A geometric approach to separate the effects of magnetic susceptibility and chemical shift/exchange in a phantom with isotropic magnetic susceptibility [PDF]
arXiv, 2020 Purpose: To separate the effects of magnetic susceptibility and chemical shift/exchange in a phantom with isotropic magnetic susceptibility. To generate a chemical shift/exchange-corrected quantitative susceptibility mapping (QSM) result. Theory and Methods: Magnetic susceptibility and chemical shift/exchange are the properties of a material.
arxiv
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Thermodynamically predicted oscillations in closed chemical systems [PDF]
arXiv, 2010 All known up to now models of chemical oscillations are based exclusively on kinetic considerations. The chemical gross-process equation is split usually by elementary steps, each step is supplied by an arrow and a differential equation, joint solution to such a construction under certain, often ad hoc chosen conditions and with ad hoc numerical ...
arxiv