Results 41 to 50 of about 1,256,952 (297)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Review: Electrostatically actuated nanobeam-based nanoelectromechanical switches – materials solutions and operational conditions

Beilstein Journal of Nanotechnology, 2018
This review summarizes relevant research in the field of electrostatically actuated nanobeam-based nanoelectromechanical (NEM) switches. The main switch architectures and structural elements are briefly described and compared.
Liga Jasulaneca, Jelena Kosmaca, Raimonds Meija, Jana Andzane, Donats Erts   +4 more
doaj   +1 more source

Pressure-induced superconductivity and modification of Fermi surface in type-II Weyl semimetal NbIrTe4

npj Quantum Materials, 2021
Weyl semimetals (WSMs) hosting Weyl points (WPs) with different chiralities attract great interest as an object to study chirality-related physical properties, topological phase transitions, and topological superconductivity.
Qing-Ge Mu, Feng-Ren Fan, Horst Borrmann, Walter Schnelle, Yan Sun, Claudia Felser, Sergey Medvedev   +6 more
doaj   +1 more source

The s Process: Nuclear Physics, Stellar Models, Observations

, 2010
Nucleosynthesis in the s process takes place in the He burning layers of low mass AGB stars and during the He and C burning phases of massive stars. The s process contributes about half of the element abundances between Cu and Bi in solar system material.
Allen, B., Aoki, W., Aoki, W., Beer, H., Beer, H., Bisterzo, S., Bisterzo, S., Borella, A., Bradley, T., Chau, L., Christlieb, N., Clayton, D., Cristallo, S., de L. Musgrove, A., Diehl, R., Dillmann, I., Dillmann, I., Dupraz, C., Edvardsson, B., F. Käppeler, F. Rau, Freytag, B., Fürst, E., Gallino, R., Goriely, S., Gratton, R., Guber, K., Herwig, F., Herwig, F., Hill, V., Jehin, E., Koning, A., Käppeler, F., Lambert, D., Langer, N., Lisowski, P., Macklin, R., Macklin, R., Macklin, R., Macklin, R., Meusel, O., Perey, F., Prantzos, N., Péquignot, D., R. Gallino, Ratzinger, U., Rau, F., S. Bisterzo, Sadakane, K., Spencer, R., Straniero, O., Suda, T., Tain, J., Thielemann, F.-K., Van Winckel, H., Wako Aoki, Ward, R., Weigert, A., Wisshak, K., Woodward, P.   +59 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

DNA-decorated graphene chemical sensors

, 2010
Graphene is a true two dimensional material with exceptional electronic properties and enormous potential for practical applications. Graphene's promise as a chemical sensor material has been noted but there has been relatively little work on practical ...
Goldsmith, Brett R., Johnson, A. T. Charlie, Kybert, Nicholas J., Lu, Ye   +3 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source