Results 61 to 70 of about 7,143,717 (276)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Gamification and Physics and Chemistry of Secondary Education
Education in the Knowledge Society, 2016 Research proposal was made during the 2014–2015 school year with 4th year’s students of Secondary Education who have chosen as optional the subject of Physics and Chemistry.
Felipe QUINTANAL PEREZ
doaj +1 more source
Chemical physics of materials [PDF]
The Journal of Chemical Physics, 2020 Emily A. Weiss +6 more
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Membro di Editorial Board di Physical Chemistry Chemical Physics
, 2000 Membro di Editorial Board di Physical Chemistry Chemical Physics nel periodo 2000 ...
DE SANTIS, Pasquale
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
AIP AdvancesUnderground chemical explosive testing has been conducted at the Nevada National Security Site under Physics Experiment 1 (PE1) to generate data for multi-physics signature collection and model prediction validation.
Andrew Wright +5 more
doaj +1 more source
Negative magnetoresistance without well-defined chirality in the Weyl semimetal TaP
Nature Communications, 2016 Magnetoresistance of topological semimetal shows unusual electron transport behaviour. Here, Arnold et al. demonstrate detailed Fermi surface topology of Weyl semimetal TaP and show that negative longitudinal magnetoresistance shows up without well ...
Frank Arnold +17 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source