Results 61 to 70 of about 753,952 (338)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Synthesis and Research of Alumina Ceramics Properties

Chimica Techno Acta, 2020
The article describes in detail alumina powder synthesis by different methods at varying parameters. The technique of obtaining ceramics and the research of the optical properties for determining the materials with the maximum luminescence efficiency is ...
Evgeniy I. Frolov, Polina V. Notina, Sergey V. Zvonarev, Evgeniya A. Il'ina, Vyacheslav Yu. Churkin   +4 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Obtención de tetróxido de trimanganeso (Hausmanita) y sulfato de potasio a partir de residuos de laboratorio [PDF]

Avances en Química, 2009
Obtainment of trimanganese tetroxide (Hausmanite) and potassium sulfate from laboratory wastes. In the laboratory practices a great amount of solutions is generated that, by their dangerous characteristics, cannot be rejected to the environment.
Katiuska Ramos
doaj  

Characterization and Photocatalytic Performance of Newly Synthesized ZnO Nanoparticles for Environmental Organic Pollutants Removal from Water System

Separations, 2023
Most countries are facing problems of environmental pollution due to toxic organic pollutants being discharged into the environment from various man-made sources.
Vesna Despotović, Nina Finčur, Sabolč Bognar, Daniela Šojić Merkulov, Predrag Putnik, Biljana Abramović, Sanja Panić   +6 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Hydrothermal Desorption of Cs with Oxalic Acid from Hydrobiotite and Wastewater Treatment by Chemical Precipitation

Energies, 2020
A hydrobiotite (HBT) clay contains more cesium (Cs)-specific adsorption sites than illitic clay, and the capacity of frayed edge sites can increase as the weathering of micaceous minerals proceeds. Thus, Cs can be selectively adsorbed to HBT clay.
Sung-Man Kim, In-Ho Yoon, Ilgook Kim, June-Hyun Kim, So-Jin Park   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

The effects of precipitation chemistry and catchment area lithology on the quality of river water in selected catchments in eastern Australia [PDF]

, 1968
The results of partial chemical analyses of precipitation and river water samples from north-east Queensland and south-eastern New South Wales are presented. Comparisons of water quality in the two areas are made using ionic ratios.
Douglas, Ian
core   +1 more source