Results 81 to 90 of about 777,399 (277)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Motif Analysis for Small-Number Effects in Chemical Reaction Dynamics

, 2016
The number of molecules involved in a cell or subcellular structure is sometimes rather small. In this situation, ordinary macroscopic-level fluctuations can be overwhelmed by non-negligible large fluctuations, which results in drastic changes in ...
Kaneko, Kunihiko, Saito, Nen, Sughiyama, Yuki   +2 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Interpretation of chemical reaction yields with graph neural additive network

Machine Learning: Science and Technology
Prediction of chemical yields is crucial for exploring untapped chemical reactions and optimizing synthetic pathways for targeted compounds. Recently, graph neural networks have proven successful in achieving high predictive accuracy.
Youngchun Kwon, Yongsik Jung, Youn-Suk Choi, Seokho Kang   +3 more
doaj   +1 more source

Carbon monoxide in the solar atmosphere I. Numerical method and two-dimensional models

, 2005
The radiation hydrodynamic code CO5BOLD has been supplemented with the time-dependent treatment of chemical reaction networks. Advection of particle densities due to the hydrodynamic flow field is also included.
Asensio Ramos, Asplund, Asplund, Ayres, Ayres, Ayres, Ayres, Ayres, Ayres, Ayres, B. Freytag, Baulch, Brown, Carlson, Carlsson, Carlsson, Carlsson, Cohen, Dalgarno, Farmer, Fontenla, Freytag, Goorvitch, Hauschildt, Herbst, I. Kamp, Iglesias, J. Bruls, Jacobs, Le Teuff, Leenaarts, Millar, Mitchell, Noyes, Noyes, Palla, Petuchowski, Prasad, S. Wedemeyer-Böhm, Solanki, Stein, Uitenbroek, Uitenbroek, Uitenbroek, Vernazza, Wedemeyer, Westley, Wiedemann   +47 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A Theoretical Simulation of Deformed Carbon Nanotubes with Adsorbed Metal Atoms: Enhanced Reactivity by Deformation

, 2010
First-principles simulations were performed to investigate reaction of carbon nanotubes with adsorbed metal atoms. Mechanical modification of their structures enhances chemical reactivity of carbon nanotubes.
Amelinckx, Carroll, Chandra, Charlier, Charlier, Conversano, David, Duong, Durgun, Ebbsesen, Fujita, Giannozzi, Hohenberg, Horner, Iijima, Inoue, Jiang, Jin-Phillipp, Kim, Kohn, Koichi Kusakabe, Li, Martel, Meunier, Miyake, Naoki Hosoya, Nardelli, Nardelli, Novoselov, Perdew, Perdew, Picozzi, Pozrikidis, S. Uma Maheswari, Seo, Stone, Suenaga, Tans, Tekleab, Terrones, Thess, Vanderbilt, Wako, Wong, Yakobson, Yang, Yang, Yang, Zhang, Zhou, Zhuang   +50 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Skewness and Kurtosis in Statistical Kinetics

, 2015
We obtain lower and upper bounds on the skewness and kurtosis associated with the cycle completion time of unicyclic enzymatic reaction schemes. Analogous to a well known lower bound on the randomness parameter, the lower bounds on skewness and kurtosis ...
Barato, Andre C., Seifert, Udo
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source