Results 91 to 100 of about 254,055 (254)

Networking chemical robots for reaction multitasking

Nature Communications, 2018
Distributing a reaction workload across laboratories can solve chemical problems more efficiently, but it is challenging to develop viable hardware and software.
Dario Caramelli, Daniel Salley, Alon Henson, Gerardo Aragon Camarasa, Salah Sharabi, Graham Keenan, Leroy Cronin   +6 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Catalyst Initiation in the Oscillatory Carbonylation Reaction

International Journal of Chemical Engineering, 2011
Palladium(II) iodide is used as a catalyst in the phenylacetylene oxidative carbonylation reaction that has demonstrated oscillatory behaviour in both pH and heat of reaction.
Katarina Novakovic, Julie Parker
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

SOME PROBLEMS OF CHEMICAL REACTIONS RETRIEVAL SYSTEMS

TASK Quarterly, 1998
The paper briefly discusses some organisational questions of distribution of chemical information over the computer network, emphasizing various tools available for chemical sciences, mainly: chemical reaction retriev all systems, systems for computer ...
ZDZISŁAW S. HIPPE
doaj  

Automated Chemical Reaction Network Generation and Its Application to Exoplanet Atmospheres

The Astrophysical Journal
With the advent of JWST and the spectroscopic characterization of exoplanet atmospheres in unprecedented detail, there is a demand for more complete pictures of chemical and photochemical reactions and their impacts on atmospheric composition ...
Jeehyun Yang, Renyu Hu
doaj   +1 more source

Approaching coupled cluster accuracy with a general-purpose neural network potential through transfer learning

Nature Communications, 2019
Computational modelling of chemical systems requires a balance between accuracy and computational cost. Here the authors use transfer learning to develop a general purpose neural network potential that approaches quantum-chemical accuracy for reaction ...
Justin S. Smith, Benjamin T. Nebgen, Roman Zubatyuk, Nicholas Lubbers, Christian Devereux, Kipton Barros, Sergei Tretiak, Olexandr Isayev, Adrian E. Roitberg   +8 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Vertex-degree-based topological indices of uniform directed hypergraphs

Arab Journal of Basic and Applied Sciences
Modelling a chemical network is crucial for understanding the complex interactions and dynamics within a chemical system, allowing for precise predictions of reaction behaviour under various conditions.
Shashwath S. Shetty, K. Arathi Bhat
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source