Results 141 to 150 of about 445,407 (250)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Strong parameter hierarchy in the interstellar phosphorus chemical network

Frontiers in Astronomy and Space Sciences
Phosphorus-bearing molecules are fundamental for life on Earth, yet their astrochemical origins remain poorly understood. Their formation in the interstellar medium has been challenging to elucidate due to limited spectroscopic detections and the ...
Marina Fernández-Ruz, Marina Fernández-Ruz, Izaskun Jiménez-Serra, Mario Castro, Mario Castro, Marta Ruiz-Bermejo, Jacobo Aguirre, Jacobo Aguirre   +7 more
doaj   +1 more source

Programming and training rate-independent chemical reaction networks. [PDF]

Proc Natl Acad Sci U S A, 2022
Vasić M, Chalk C, Luchsinger A, Khurshid S, Soloveichik D.   +4 more
europepmc   +1 more source

Universal slow dynamics of chemical reaction networks

Physical Review E
Understanding the emergent behavior of chemical reaction networks (CRNs) is a fundamental aspect of biology and its origin from inanimate matter. A closed CRN monotonically tends to thermal equilibrium, but when it is opened to external reservoirs, a range of behaviors is possible, including transition to a new equilibrium state, a non-equilibrium ...
Masanari Shimada, Pegah Behrad, Eric De Giuli   +2 more
openaire   +3 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

A structural approach to understanding enzymatic regulation of chemical reaction networks. [PDF]

Biochem J, 2022
Mochizuki A.
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Polynomial superlevel set representation of the multistationarity region of chemical reaction networks. [PDF]

BMC Bioinformatics, 2022
Sadeghimanesh A, England M.
europepmc   +1 more source

Properties of Random Complex Chemical Reaction Networks and Their Relevance to Biological Toy Models

, 2013
We investigate the properties of large random conservative chemical reaction networks composed of elementary reactions endowed with either mass-action or saturating kinetics, assigning kinetic parameters in a thermodynamically-consistent manner.
Bigan, Erwan, Douady, Stéphane, Steyaert, Jean-Marc   +2 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source