Results 71 to 80 of about 447,849 (263)

Composable computation in discrete chemical reaction networks

, 2019
We study the composability of discrete chemical reaction networks (CRNs) that stably compute (i.e., with probability 0 of error) integer-valued functions $f:\mathbb{N}^d\to\mathbb{N}$.
Doty, David, Haley, David, Severson, Eric E.   +2 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Stability Analysis for a Class of Non-Weakly Reversible Chemical Reaction Networks

SICE Journal of Control, Measurement, and System Integration, 2018
We consider ordinary differential equations (ODEs) that describe the time evolution of the concentrations of species in chemical reaction networks (CRNs).
Hirokazu Komatsu, Hiroyuki Nakajima
doaj   +1 more source

Computational Complexity of Atomic Chemical Reaction Networks

, 2017
Informally, a chemical reaction network is "atomic" if each reaction may be interpreted as the rearrangement of indivisible units of matter. There are several reasonable definitions formalizing this idea.
A Padirac, A Silberschatz, B Yurke, CH Papadimitriou, D Angeli, D Angluin, D Doty, D Soloveichik, D Soloveichik, EW Mayr, G Craciun, G Gnacadja, G Seelig, H Jiang, HL Chen, J Esparza, J Leroux, K Oishi, L Adleman, L Qian, L Qian, MR Garey, R Brijder, S Chubanov, S Ginsburg, SA Salehi, WJ Savitch, YE Lien, YJ Chen   +28 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Theoretical Framework for Implementable Nucleic Acids Feedback Systems

Bioengineering, 2023
Chemical reaction networks can be utilised as basic components for nucleic acid feedback control systems’ design for Synthetic Biology application. DNA hybridisation and programmed strand-displacement reactions are effective primitives for implementation.
Nuno M. G. Paulino, Mathias Foo, Tom F. A. de Greef, Jongmin Kim, Declan G. Bates   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

In-silico modelling of the mitogen-activated protein kinase (MAPK) pathway in colorectal cancer: mutations and targeted therapy

Frontiers in Systems Biology, 2023
Introduction: Chemical reaction networks (CRNs) are powerful tools for describing the complex nature of cancer’s onset, progression, and therapy. The main reason for their effectiveness is in the fact that these networks can be rather naturally encoded ...
Sara Sommariva, Silvia Berra, Giorgia Biddau, Giacomo Caviglia, Federico Benvenuto, Michele Piana, Michele Piana   +6 more
doaj   +1 more source

Exploration of Reaction Pathways and Chemical Transformation Networks

, 2018
For the investigation of chemical reaction networks, the identification of all relevant intermediates and elementary reactions is mandatory. Many algorithmic approaches exist that perform explorations efficiently and automatedly.
Reiher, Markus, Simm, Gregor N., Vaucher, Alain C.   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source