Results 81 to 90 of about 447,849 (263)

Noise-robust training of artificial neural networks using chemical reaction networks

APL Machine Learning
Artificial neural networks (NNs) can be implemented using chemical reaction networks (CRNs), where the concentrations of species act as inputs and outputs.
Sunghwa Kang, Jinsu Kim
doaj   +1 more source

Cascade PID Control Systems Based on DNA Strand Displacement With Application in Polarization of Tumor-Associated Macrophages

IEEE Access, 2023
Disturbances are widespread in biochemical systems. Nowadays, prevalent single-loop control strategies only take external disturbances into account. However, internal perturbations that threaten the stability of biochemical systems are invariably ignored.
Huihui Xue, Hui Lv, Yijun Xiao, Xing'an Wang   +3 more
doaj   +1 more source

Splitting Reactions Preserves Nondegenerate Behaviors in Chemical Reaction Networks

SIAM Journal on Applied Mathematics, 2023
some minor calculational errors fixed in the ...
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Heuristics-Guided Exploration of Reaction Mechanisms

, 2015
For the investigation of chemical reaction networks, the efficient and accurate determination of all relevant intermediates and elementary reactions is mandatory.
Bergeler, Maike, Proppe, Jonny, Reiher, Markus, Simm, Gregor N.   +3 more
core   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Reaction cleaving and complex-balanced distributions for chemical reaction networks with general kinetics

Peer Community Journal
Reaction networks have become a major modelling framework in the biological sciences from epidemiology and population biology to genetics and cellular biology.
Hoessly, Linard, Wiuf, Carsten, Xia, Panqiu   +2 more
doaj   +1 more source

Reaction Network Viewer (ReNView): An open-source framework for reaction path visualization of chemical reaction systems

SoftwareX, 2020
Reaction Path Analysis (RPA) is an essential tool in identifying the key reaction pathways that drive chemical transformations of complex reaction networks.
Udit Gupta, Dionisios G. Vlachos
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source