Results 111 to 120 of about 919,666 (317)

EnzymeMap: curation, validation and data-driven prediction of enzymatic reactions

Enzymatic reactions are an ecofriendly, selective, and versatile addition, sometimes even alternative to organic reactions for the synthesis of chemical compounds such as pharmaceuticals or fine chemicals.
Probst, Daniel, Madsen, Georg KH, Green, William H, Heid, Esther   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Synergistic modulation of valence state and oxygen vacancy induced by surface reconstruction of the CeO2/CuO catalyst toward enhanced electrochemical CO2 reduction

Carbon Energy
Electrochemical CO2 reduction reaction (CO2RR) offers a promising strategy for CO2 conversion into value‐added C2+ products and facilitates the storage of renewable resources under comparatively mild conditions, but still remains a challenge.
Fangfang Chang, Zhenmao Zhang, Yan Zhang, Yongpeng Liu, Lin Yang, Xiaolei Wang, Zhengyu Bai, Qing Zhang   +7 more
doaj   +1 more source

RETRASO, a code for modeling reactive transport in saturated and unsaturated porous media

, 2004
The code RETRASO (REactive TRAnsport of SOlutes) simulates reactive transport of dissolved and gaseous species in non-isothermal saturated or unsaturated problems.
Saaltink, Maarten, Ayora, Carles, Carrera Ramírez, Jesús, Ayora Ibáñez, Carlos, Olivella Pastallé, Sebastià, Ayora, C., Olivella, Sebastià, Saaltink, Maarten W., Olivella, S., Ayora, Carlos, Batlle, F., Carrera, J., Batlle Pifarré, Francisco, Carrera, Jesús   +13 more
core   +1 more source

Translated Chemical Reaction Networks

Bulletin of Mathematical Biology, 2014
Many biochemical and industrial applications involve complicated networks of simultaneously occurring chemical reactions. Under the assumption of mass action kinetics, the dynamics of these chemical reaction networks are governed by systems of polynomial ordinary differential equations.
openaire   +4 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Measurements of complex refractive index change of photoactive yellow protein over a wide wavelength range using hyperspectral quantitative phase imaging

Scientific Reports, 2018
A novel optical holographic technique is presented to simultaneously measure both the real and imaginary components of the complex refractive index (CRI) of a protein solution over a wide visible wavelength range.
KyeoReh Lee, Youngmin Kim, JaeHwang Jung, Hyotcherl Ihee, YongKeun Park   +4 more
doaj   +1 more source

Conditional moment closure for chemical reactions in laminar chaotic flows [PDF]

, 2007
We implement conditional moment closure (CMC) for simulation of chemical reactions in laminar chaotic flows. The CMC approach predicts the expected concentration of reactive species, conditional upon the concentration of a corresponding nonreactive ...
Cox, Stephen M., Vikhansky, A.
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source