Results 91 to 100 of about 5,534,558 (317)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Characterization of VOCs at Shaoxing in the Winter Campaign: Sources and Chemical Reactivity

Atmosphere
Despite recent improvements in particulate matter (PM) pollution, haze events still frequently occur in many regions of China. Volatile organic compounds (VOCs), as key precursors in atmospheric photochemistry, play a crucial role in haze formation.
Dongfeng Shi, Yan Lyu, Junpeng Song, Qing Ren, Xing Chen, Liyong Hu, Wenting Zhuge, Kewen Hu, Dongmei Cai, Xianda Gong, Jianmin Chen   +10 more
doaj   +1 more source

Impedance spectroscopy of perovskite/contact interface: Beneficial chemical reactivity effect.

Journal of Chemical Physics, 2019
Understanding chemical reactivity of lead halide perovskite materials with contacts is crucial to improve the stability of these optoelectronic devices.
C. Aranda, J. Bisquert, Antonio Guerrero
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bond-specific reaction kinetics during the oxidation of (111) Si: Effect of n-type doping

, 2010
It is known that a higher concentration of free carriers leads to a higher oxide growth rate in the thermal oxidation of silicon. However, the role of electrons and holes in oxidation chemistry is not clear.
Aspnes, David E., Gokce, Bilal, Gundogdu, Kenan, Lucovsky, Gerald   +3 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Chemical Reactivity Properties, pKa Values, AGEs Inhibitor Abilities and Bioactivity Scores of the Mirabamides A–H Peptides of Marine Origin Studied by Means of Conceptual DFT

Marine Drugs, 2018
The MN12SX density functional, in connection with the Def2TZVP basis set, was assessed, together with the SMD solvation model (Solvation Model based on the Density), for calculation of the molecular properties and structure of a group of peptides of ...
Juan Frau, Norma Flores-Holguín, Daniel Glossman-Mitnik   +2 more
doaj   +1 more source

Chemical Reactivity of Hydrogen, Nitrogen and Oxygen Atoms at Temperatures Below 100 deg K Semiannual report, 1 Jul. - 31 Dec. 1966 [PDF]

Chemical reactivity of hydrogen, nitrogen, and oxygen atoms at temperatures below 100 deg
Knight, James A., Jr.
core   +1 more source

Bases of inorganic and organic chemistry [PDF]

, 2016
Stated fundamental theoretical principles of general, inorganic and organic chemistry and analyzed the reactivity of the most important classes of inorganic and organic substances. A multivariate tasks and exercises for classroom and independent work are
Alami, D., Slavkova, M., Ved, M.
core  

Chemical Reactivity Theory and Empirical Bioactivity Scores as Computational Peptidology Alternative Tools for the Study of Two Anticancer Peptides of Marine Origin

Molecules, 2019
This work presents an account of the reactivity behavior of the anticancer marine drugs, Soblidotin and Tasidotin, based on the calculation of the global and local descriptors resulting from Chemical Reactivity Theory (CRT), also known as Conceptual DFT,
J. Frau, N. Flores-Holguín, D. Glossman‐Mitnik   +2 more
semanticscholar   +1 more source