Results 91 to 100 of about 11,630,444 (338)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Connecting the Chemical and Biological Reactivity of Epoxides [PDF]

Chemical Research in Toxicology, 2012
The chemical reactivity of the mutagenic epoxides (EP) propylene oxide (PO), 1,2-epoxybutane (1,2-EB), and cis- and trans-2,3-epoxybutane (cis- and trans-2,3-EB) with 4-(p-nitrobenzyl)pyridine (NBP), a bionucleophile model for S(N)2 alkylating agents with high affinity for the guanine-N7 position, was investigated kinetically.
González Pérez, Marina, Gómez-Bombarelli, Rafael, Arenas Valgañón, Jorge, Pérez Prior, María Teresa, García Santos, María Pilar, Calle Martín, Emilio, Casado, Julio   +6 more
openaire   +4 more sources

RE-IGNITION OF MULTI-SPECIES SOOT CLOUDS IN BUILDING FIRES [PDF]

, 2007
The re-ignition potential of multi-species soot clouds in building fires were investigated based on their extinction characteristics. The investigation was carried out theoretically using an adaptation of Semenov’s thermal explosion theory.
Moghtaderi, B., Poespowati, T.
core   +1 more source

Reactivity-Controlled Preparation of Ultralarge Graphene Oxide by Chemical Expansion of Graphite

, 2017
The production of ultralarge graphene oxide (ULGO) is hindered by sluggish diffusion process of the oxidizing agents into graphite layers, as well as sheet fracture resulting from inhomogeneous oxidation.
Lei Dong (165252), Shan Lin (228596), Zhongxin Chen (1760725), Ke Wang (82395), Hongbin Lu (724174), Chen Ma (714759)   +5 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Characterization of VOCs at Shaoxing in the Winter Campaign: Sources and Chemical Reactivity

Atmosphere
Despite recent improvements in particulate matter (PM) pollution, haze events still frequently occur in many regions of China. Volatile organic compounds (VOCs), as key precursors in atmospheric photochemistry, play a crucial role in haze formation.
Dongfeng Shi, Yan Lyu, Junpeng Song, Qing Ren, Xing Chen, Liyong Hu, Wenting Zhuge, Kewen Hu, Dongmei Cai, Xianda Gong, Jianmin Chen   +10 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A Structure-Based Platform for Predicting Chemical Reactivity

Chem, 2019
Despite their enormous potential, machine learning methods have only found limited application in predicting reaction outcomes, as current models are often highly complex and, most importantly, are not transferrable to different problem sets.
Frederik Sandfort, Felix Strieth-Kalthoff, Marius Kühnemund, C. Beecks, F. Glorius   +4 more
semanticscholar   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Chemical Reactivity Properties, pKa Values, AGEs Inhibitor Abilities and Bioactivity Scores of the Mirabamides A–H Peptides of Marine Origin Studied by Means of Conceptual DFT

Marine Drugs, 2018
The MN12SX density functional, in connection with the Def2TZVP basis set, was assessed, together with the SMD solvation model (Solvation Model based on the Density), for calculation of the molecular properties and structure of a group of peptides of ...
Juan Frau, Norma Flores-Holguín, Daniel Glossman-Mitnik   +2 more
doaj   +1 more source