Results 181 to 190 of about 6,218,927 (299)

[Contribution to the theoretical study of chemical reactivity]

, 1974
The following three approaches are used to theoretically analyze chemical reactivity: reactivity indices, correlation diagrams, potential energy surfaces.
Louterman-Leloup, G., Metzger, J., Deschamps, J., Leroy, Georges   +3 more
core  

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

A Phenomenological Symmetry Rule for Chemical Reactivity Under Vibrational Strong Coupling. [PDF]

Angew Chem Int Ed Engl
Jayachandran A, Patrahau B, Ricca JG, Mahato MK, Pang Y, Nagarajan K, Thomas A, Genet C, Ebbesen TW.   +8 more
europepmc   +1 more source

Protocol for using organic persulfides to measure the chemical reactivity of persulfide sensors. [PDF]

STAR Protoc, 2022
Fakhoury JN, Capdevila DA, Giedroc DP.
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Chemical reactivity of 2-methylchromone with some nitrogen-based nucleophiles: reactions, DFT analysis, anticancer activity and molecular docking studies. [PDF]

RSC Adv
Abdel-Megid M, Alshaye NA, Badran AS, Ibrahim MA.   +3 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Chemical reactivity of RNA and its modifications with hydrazine. [PDF]

Commun Chem
Yeşiltaç-Tosun N, Qi Y, Li C, Stafflinger H, Hollnagel K, Rusling L, Wöhnert J, Kaiser S, Kaiser S.   +8 more
europepmc   +1 more source

Triplet-driven chemical reactivity of β-carotene and its biological implications. [PDF]

Nat Commun, 2022
Zbyradowski M, Duda M, Wisniewska-Becker A, Heriyanto, Rajwa W, Fiedor J, Cvetkovic D, Pilch M, Fiedor L.   +8 more
europepmc   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source