Results 81 to 90 of about 487,810 (325)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Global chemical reactivity parameters for several chiral beta-blockers from the Density Functional Theory viewpoint

Clujul Medical, 2016
Background and aim Beta-adrenergic antagonists have been established as first line treatment in the medical management of hypertension, acute coronary syndrome and other cardiovascular diseases, as well as for the prevention of initial episodes of ...
Mona Talmaciu, E. Bodoki, R. Oprean
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Rotation in attosecond vibronic coherence spectroscopy for molecules

Communications Physics
Excitation or ionization of a molecule by ultrafast laser pulses can create a superposition of electronic states, whose dynamics is influenced by the interplay of electronic coherence and nuclear motion, resulting in charge migration and possibly charge ...
Chi-Hong Yuen, Chii-Dong Lin
doaj   +1 more source

A new approach to local hardness

, 2011
The applicability of the local hardness as defined by the derivative of the chemical potential with respect to the electron density is undermined by an essential ambiguity arising from this definition. Further, the local quantity defined in this way does
Ayers, Ayers, Ayers, Ayers, Becke, Becke, Berkowitz, Borgoo, Broadus, Cedillo, Chattaraj, Chattaraj, Chattaraj, Chermette, Clarke, De Proft, De Proft, F. De Proft, Frisch, Fuentealba, Galván, Garza, Geerlings, Geerlings, Ghanty, Ghosh, Ghosh, Gál, Gál, Gál, Gál, Gál, Gál, Gál, Gál, Gázquez, Harbola, Hehre, Koenig, Langenaeker, Lee, Levedev, Liu, Liu, M. Torrent-Sucarrat, Melin, Meneses, Meneses, Mignon, Mignon, Mulliken, Nagy, Nagy, Olasz, Ozen, P. Geerlings, Parr, Parr, Parr, Parr, Pearson, Pearson, Pearson, Pearson, Perdew, Roy, Saha, Saha, Saha, Sanderson, Slater, T. Gál, Thomas, Torrent-Sucarrat, Torrent-Sucarrat, Torrent-Sucarrat, Torrent-Sucarrat, Torrent-Sucarrat, Torrent-Sucarrat, Torrent-Sucarrat, Torrent-Sucarrat, Uline, Uline, Vargas, Yang, Zhou   +85 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Synthesis, X-ray Structures, Electronic Properties, and O\u3csub\u3e2\u3c/sub\u3e/NO Reactivities of Thiol Dioxygenase Active-Site Models [PDF]

, 2016
Mononuclear non-heme iron complexes that serve as structural and functional mimics of the thiol dioxygenases (TDOs), cysteine dioxygenase (CDO) and cysteamine dioxygenase (ADO), have been prepared and characterized with crystallographic, spectroscopic ...
Brunold, Thomas C., Fiedler, Adam T., Fischer, Anne A., Lindeman, Sergey V., Stracey, Nuru   +4 more
core   +1 more source

Global and local aromaticity of acenes from the information-theoretic approach in density functional reactivity theory.

Physical Chemistry, Chemical Physics - PCCP, 2019
In this work, we report a systematic study on the global and local aromaticity of acenes using a series of model structures from 2-acene to 11-acene.
Donghai Yu, T. Stuyver, Chunying Rong, M. Alonso, T. Lu, F. de Proft, P. Geerlings, Shubin Liu   +7 more
semanticscholar   +1 more source