Results 41 to 50 of about 1,417,488 (251)
Scientific Reports, 2022 The chemical risk assessment paradigm is shifting from “substance-based” to “product/mixture-based” and from “animal testing” to “alternative testing” under chemical regulations.
Jongwoon Kim +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Studia Historiae Scientiarum, 2018 The article discusses the issues of implementation of important achievements in the field of metallurgy (including armored weapons, fortifications and the navy), under the supervision of prof.
Mariusz W. Majewski
doaj +1 more source
Journal of Natural Fibers, 2023 The demand for face masks is increasing exponentially due to the coronavirus pandemic and the particulate matter (PM) in the atmosphere. As a result, an enormous number of disposable mask filters have been produced and discarded, contributing to plastic ...
Minkyung Lee +6 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A Case of Mass Poisoning with Thallium
Неотложная медицинская помощь, 2019 We report the results of studies of clinical manifestations, chemical and toxico-logical tests, efficacy of complex treatment, which included antidote therapy, intestinal lavage and symptomatic treatment in patients with acute thallium poisoning, who ...
M. M. Potskhveriya +7 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Journal of Human Environmental Studies, 2008 Lead-acid batteries for SLI (engine starting, lighting, ignition) uses have an average life of 3-4 years. The ITE Yeager Battery Research Institute (Japan) has developed a new chemical (organic polymer) which prevents sulfation of new batteries and ...
Hajimu Ikeda +4 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source