Results 81 to 90 of about 1,559,834 (252)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Генрих Цейсс и московские “германофилы” 1920-х годов
Acta Medico-Historica Rigensia, 2000 Доддубный, М. В.
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Women in chemistry: Q&A with Professor Hyunjoo Lee
Communications ChemistryProf. Hyunjoo Lee is a Full Professor in the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science & Technology (KAIST), Korea, and a KAIST Endowed Chair Professor.
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Hazardous Chemical Laboratory Fire Risk Assessment Based on ANP and 3D Risk Matrix
FireThe laboratory is a high-risk place for scientific research and learning, and there are many risk factors and great potential for harm. Hazardous chemicals are important to consider and are the key objects to monitor in a laboratory.
Changmao Qi +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Blue Nile Journal of Agricultural ResearchCoffee production among smallholder farmers in Tanzania’s Southern Highlands faces increasing threats from pests that reduce yield and quality. Limited access to effective pest management strategies exacerbates this challenge in low-income settings ...
Luka S. Njau, Leonard K. Kiwelu
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source