Results 61 to 70 of about 1,129,922 (280)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Challenges and Perspectives of Chemical Biology, a Successful Multidisciplinary Field of Natural Sciences

Molecules, 2011
Objects, goals, and main methods as well as perspectives of chemical biology are discussed. This review is focused on the fundamental aspects of this emerging field of life sciences: chemical space, the small molecule library and chemical sensibilization
Vladimir V. Kouznetsov, Fernando A. Rojas-Ruiz, Leonor Y. Vargas-Méndez   +2 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Generative Models as an Emerging Paradigm in the Chemical Sciences. [PDF]

J Am Chem Soc, 2023
Anstine DM, Isayev O.
europepmc   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Flipping the Thinking on Equality, Diversity, and Inclusion. Why EDI Is Essential for the Development and Progression of the Chemical Sciences: A Case Study Approach. [PDF]

J Chem Educ, 2023
Khan MAH, Harrison TG, Wajrak M, Grimshaw M, Schofield KG, Trew AJ, Johal K, Morgan J, Shallcross KL, Sewry JD, Davies-Coleman MT, Shallcross DE.   +11 more
europepmc   +1 more source

Editorial: Frontiers in Chemistry: rising stars 2022

Frontiers in Chemistry, 2023
Carlos D. S. Brites, Daniele Contini, Xiao-Peng He, Tianqing Liu, Basem Moosa, Marianna Pannico, Mohamed Nageeb Rashed, Yunping Qiu, Clemens Zwergel   +8 more
doaj   +1 more source

Protocol for producing phosphoramidate using phosphorus fluoride exchange click chemistry

STAR Protocols
Summary: Phosphorus fluoride exchange (PFEx) is a catalytic click reaction that involves exchanging high oxidation state P–F bonds with alcohol and amine nucleophiles, reliably yielding P–O- and P–N-linked compounds. Here, we describe steps for preparing
Joshua A. Homer, Shoujun Sun, Rebecca A. Koelln, John E. Moses   +3 more
doaj   +1 more source

Sull'inadeguatezza della mereologia formale husserliana per l'ontologia regionale degli insiemi chimici

Philosophy Kitchen, 2019
In his book, History as a Science and the System of the Sciences, Thomas Seebohm articulates the view that history can serve to mediate between the sciences of explanation and the sciences of interpretation, that is, between the natural sciences and the ...
Marina Paola Banchetti-Robino
doaj   +1 more source