Results 121 to 130 of about 206,531 (296)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Chemical Sensor Technologies for Sustainable Development: Recent Advances, Classification, and Environmental Monitoring

Advanced Sensor Research
One of the significant issues of concern in recent times is detecting, quantifying, and monitoring various chemical contaminants in the environment. Numerous inorganic and organic substances are discharged into the environment from various anthropogenic ...
Abel Inobeme, Arunadevi Natarajan, Safalmani Pradhan, Charles Oluwaseun Adetunji, Alexander Ikechukwu Ajai, Jonathan Inobeme, Mathew John Tsado, John Olusanya Jacob, Shyam S. Pandey, Kshitij RB Singh, Jay Singh   +10 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Gate Engineering in Two-Dimensional (2D) Channel FET Chemical Sensors: A Comprehensive Review of Architectures, Mechanisms, and Materials

Field-effect transistor (FET) chemical sensors are essential for enabling sophisticated lifestyles and ensuring safe working environments. They can detect a wide range of analytes, including gaseous species (NO2, NH3, VOCs), ionic compounds, and ...
Ganapathi Bharathi, Seongin Hong
core   +1 more source

Optical Chemical Sensors: Design and Applications. [PDF]

Sensors (Basel), 2023
Pizzoferrato R.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Chemical Sensors and Imaging: Molecular, Materials, and Biological Platforms. [PDF]

ACS Cent Sci, 2023
Messina MS, Chang CJ.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Magnetic Resonance Sensors

, 2013
Magnetic Resonance finds countless applications, from spectroscopy to imaging, routinely in almost all research and medical institutions across the globe.
Michael I. Newton, Morris, RH, Michael Newton, Newton, MI, Robert H. Morris, Robert Morris   +5 more
core   +1 more source