Results 41 to 50 of about 158,468 (254)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Metal Oxide Nanoarrays for Chemical Sensing: A Review of Fabrication Methods, Sensing Modes, and Their Inter-correlations

open access: yesFrontiers in Materials, 2019
In recent years, engineered nanostructure assemblies such as nanowire arrays have attracted much research attention due to their unique chemical and functional characteristics collectively. The engineered nano-assemblies usually carry the characteristics
Bo Zhang, Pu-Xian Gao
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

The role of chemisorption and physisorption in Fe-doped SnO2 acetone sensors

open access: yesSensors International
The gas sensing mechanism is one of the most important parameters of chemiresistive gas sensors, and distinguishing them opens the possibility of manipulating sensor performance. In this study, we introduced the concept of adsorption-type contribution to
Yernar Shynybekov   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Harnessing interfacial click polymerization using pyridinium-yne films as photochromic, radical generation and sensing platforms

open access: yesNature Communications
Convenient and effective fabrication of free-standing organic polymer films with tunable properties is highly desirable towards visual sensing applications. Herein, we pioneered an innovative interfacial pyridinium-yne click polymerization strategy to in
Xinyu Gou   +9 more
doaj   +1 more source

Applications of Graphene-Based Materials in Sensors

open access: yesSensors, 2020
This Special Issue compiles a set of innovative developments on the use of graphene-based materials in the fabrication of sensors. In particular, these contributions report original studies on a wide variety of sensors, such as gas sensors for NO2 or NH3
Miguel Hernaez
doaj   +1 more source

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