Results 131 to 140 of about 15,527,582 (268)
Oligonucleotide Technology – A Research Platform for Chemical Biology
CHIMIA, 2001 During the past three decades, considerable progress has been made in the field of oligonucleotide synthesis. Today, oligonucleotides and their derivatives can be prepared by highly optimised, automated procedures. They are used as sophisticated
Robert Häner
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Mathematical modeling of high temperature fuel cells
, 1981 Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1981.Includes bibliographical references.by Pablo G. Debenedetti.Thesis (M.S.)--Massachusetts Institute of Technology, Dept.
Debenedetti, Pablo G.,1953-
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Micellar structures and dynamics in aqueous solutions of PEO-PPO-PEO block copolymers [PDF]
, 1999 Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept.
Goldmints, Isabella, 1966-
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Operability studies in heat exchanger networks : analysis, control and synthesis
, 1988 Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept.
Calandranis, John Christos
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Mechanistic studies on chemical instabilities of recombinant proteins [PDF]
, 2009 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2009.Includes bibliographical references.Protein molecules are being widely used as pharmaceuticals for treating diseases ranging from diabetes and haemophilia to ...
Pan, Bin, Ph. D. Massachusetts Institute of Technology
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Hydrodynamic effects on animal cells in microcarrier bioreactors by Matthew Shane Croughan. [PDF]
, 1988 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept.
Croughan, Matthew Shane
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source