Results 141 to 150 of about 1,813,331 (307)

Chemical reactions induced in a microwave discharge. [PDF]

open access: yes, 1966
Massachusetts Institute of Technology. Dept. of Chemical Engineering. Thesis. 1966.
Brockmeier, Norman Frederick
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Prevention of biofouling in seawater desalination via initiated chemical vapor deposition (iCVD) [PDF]

open access: yes, 2014
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2014.Cataloged from PDF version of thesis.Includes bibliographical references.Biofouling, the undesirable settlement and growth of organisms, occurs immediately ...
Yang, Rong, Ph. D. Massachusetts Institute of Technology
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Amine functionalization by initiated chemical vapor deposition (iCVD) for interfacial adhesion and film cohesion [PDF]

open access: yes, 2011
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2011.Cataloged from PDF version of thesis.Includes bibliographical references.Amine functional polymer thin films provide a versatile platform for subsequent ...
Xu, Jingjing, Ph. D. Massachusetts Institute of Technology
core  

Oligonucleotide Technology – A Research Platform for Chemical Biology

open access: yesCHIMIA, 2001
During the past three decades, considerable progress has been made in the field of oligonucleotide synthesis. Today, oligonucleotides and their derivatives can be prepared by highly optimised, automated procedures. They are used as sophisticated
Robert Häner
doaj  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Simulation strategies for microfabricated chemical systems [PDF]

open access: yes, 1998
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept.
Hsing, I-Ming, 1968-
core  

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