Results 121 to 130 of about 15,527,582 (268)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A constitutive equation for carbon black filled elastomers

open access: yes, 1980
Thesis: M.S., Massachusetts Institute of Technology, Department of Chemical Engineering, 1980Includes bibliographical references.by Ravinder Kumar Oswal.M.S.M.S.
Oswal, Ravinder Kumar.
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Chemical vapor deposition of fluorocarbon films for low dielectric constant thin film applications [PDF]

open access: yes, 2000
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2000.Includes bibliographical references.This electronic version was submitted by the student author.
Lau, Kenneth Ka Shun, 1972-
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Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Modern control methods for chemical process systems

open access: yes, 2017
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2017.Cataloged from PDF version of thesis.Includes bibliographical references (pages 301-322).Strong trends in chemical engineering have led to increased ...
Paulson, Joel Anthony
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Amine functionalization by initiated chemical vapor deposition (iCVD) for interfacial adhesion and film cohesion [PDF]

open access: yes, 2011
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2011.Cataloged from PDF version of thesis.Includes bibliographical references.Amine functional polymer thin films provide a versatile platform for subsequent ...
Xu, Jingjing, Ph. D. Massachusetts Institute of Technology
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Steady spinning of synthetic silk-like fibers and transient filament stretching of semi-dilute and concentrated polymeric fluids

open access: yes, 2001
Thesis: S.M., Massachusetts Institute of Technology, Department of Chemical Engineering, 2001Includes bibliographical references (p. 111-115).by Octavia Flora Brauner.S.M.S.M.
Brauner, Octavia Flora, 1975-
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Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Computer simulation of general systems of interlinked multistaged separators

open access: yes, 1982
Thesis: M.S., Massachusetts Institute of Technology, Department of Chemical Engineering, 1982Bibliography: leaves 59-60.by Willie K. Chan.M.S.M.S.
Chan, Willie K.
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