Results 161 to 170 of about 13,150,510 (391)

Oligonucleotide Technology – A Research Platform for Chemical Biology

open access: yesCHIMIA, 2001
During the past three decades, considerable progress has been made in the field of oligonucleotide synthesis. Today, oligonucleotides and their derivatives can be prepared by highly optimised, automated procedures. They are used as sophisticated
Robert Häner
doaj  

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Chemical Processes in Printing Technology

open access: yesGlasnik hemičara, tehnologa i ekologa Republike Srpske, 2013
One of the most commonly used printing technique today is lithography. The printing plate, which is composed of printing (accept printing ink) and nonprinting (must not accept printing ink) areas is highly important factor for all printing processes.
Gojo, Miroslav, Cigula, Tomislav
openaire   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Comparison of Four Space Propulsion Methods for Reducing Transfer Times of Manned Mars Mission

open access: yes, 2015
We assess the possibility of reducing the travel time of a manned mission to Mars by examining four different propulsion methods, and keeping the mass at departure under 2,500 tonnes, for a fixed architecture. We evaluated representative systems of three
Bertolami, O.   +2 more
core  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

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