Results 191 to 200 of about 1,457,648 (311)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A quantum chemical dataset of interacting molecular pairs for chemical reaction studies. [PDF]

J Cheminform
Jang S, Na GS.
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dynamic behavior and constitutive model of marble subjected to wet-dry cycling. [PDF]

PLoS One
Liu Y, Zhai M, Yang Z, He Z.
europepmc   +1 more source

ASSESSMENT OF RADIOACTIVE AND CHEMICAL IMPURITIES IN PERTECHNETATE PRODUCED BY PHOTONUCLEAR TECHNOLOGY

N.P. Dikiy, N.V. Krasnoselskiy, Yu.V. Lyashko, O.P. Medvedeva, D.V. Medvedev   +4 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Feature Comparison and Process Optimization of Multiple Dry Etching Techniques Applied in Inner Spacer Cavity Formation of GAA NSFET. [PDF]

Nanomaterials (Basel)
Wang M, Guo X, Huang Z, Liao M, Liu T, Xu M.   +5 more
europepmc   +1 more source

Chemical Technology for Appropriate Development

, 1978
'Chemical technology for appropriate development' is basicly a critical review of the literature. It gives a conceptual analysis of so called appropriate technology and the choice of production systems for less-development countries. The role of about 40 organizations active in this emerging field are evaluated and the role of universities in this ...
openaire   +2 more sources

Measuring the Staff Technology Readiness The Case of a Multi National Chemical Company Operating in Iran

, 2007
Asgharpour Hossein
openalex   +1 more source

The Place of Law in Technology Transitions: A Case Study from Chemical Risk Assessment [PDF]

Aleksandra Čavoški, Laura Holden, Robert Lee   +2 more
openalex   +1 more source