Results 51 to 60 of about 1,457,648 (311)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Research on Science and Technology Level of Chemical Industry in China based on the Perspective of Talent Innovation Ability -a Case Study of Yangtze River Delta in China

Chemical Engineering Transactions, 2017
At present, there is no industry without chemicals. Without the chemical industry, the economy and society can hardly maintain rapid growth. However, there are some problems in the development of chemical industry such as low chemical technology and slow
Nanbing Xiao
doaj   +1 more source

Chemical sensors technology [PDF]

Journal of Korean Sensors Society, 2009
There have been continued effects to develop various types of chemical sensors according to the demands in many application fields such as safety, pollution, environment, medical engineering and food industries etc. In this review, the author intended to cover the general aspects of chemical sensors, including the history of the development, the ...
openaire   +1 more source

Chemical Technologies for Probing Glycans [PDF]

Cell, 2006
Glycans are central to many biological processes, but efforts to define their functions at the molecular level have been frustrated by a lack of suitable technologies. Here we highlight chemical tools that are beginning to address this need.
Prescher, Jennifer A., Bertozzi, Carolyn R.   +1 more
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Application of Cloud Computing in the Early Warning Management of Chemical Water Pollution Accidents

Chemical Engineering Transactions, 2018
To study the application of cloud computing technology in the early warning management of chemical water pollution accidents, the early warning management platform of chemical water pollution accidents is built based on the cloud computing technology ...
Zhentao Wu
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Center for Chemical Sensors and Chemical Information Technology (CCS): Molecular Recognition and Chemical Sensor Development at CCS

CHIMIA, 2003
The Center for Chemical Sensors and Chemical Information Technology (CCS) at ETH-Zürich has devoted its activities to the development of highly selective devices that access chemical information about the composition of a specimen.
Ursula E. Spichiger-Keller
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source