Results 101 to 110 of about 6,195,681 (305)

Midwest Transportation Consortium : 2009-2010 annual report. [PDF]

open access: yes
In October 2009, the Midwest Transportation Consortium (MTC) began its third yearas a Tier I University Transportation Center (UTC). Its theme, \u201cTransportation Safetythrough Improvements in Management Information Systems,\u201d reflects our ...
Midwest Transportation Consortium
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Maritime trade and transportation '99

open access: yes
The marine transportation system contributes to U.S. economic growth, enhances global competitiveness, and supports national security objectives.
United States. Department of Transportation. Bureau of Transportation Statistics
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

The transportation economy : just in time. [PDF]

open access: yes
DTRT06-G-0044The purpose of this project was to produce a short educational video, targeted at middle school and high school students, illustrating the critical role transportation plays in our modern economy.
Cole, Richard   +2 more
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An experimental toolbox for the physical characterization of thermal insulating polymeric foams

open access: yesHeliyon
Recent advancements in polymer science and manufacturing technologies triggered new developments of porous materials used for mitigating heat losses, such as thermal insulating polymeric foams.
S. Shrestha   +9 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A microfluidic electrochemical immunosensor for detection of CEA and Ki67 in 3D tumor spheroids

open access: yesMaterials Today Bio
Microfluidic chip-based electrochemical sensors have been developed to detect cancer biomarkers and monitor changes in the tumor microenvironment. However, the limitation of detecting only a single biomarker restricts their utility as accurate diagnostic
Sujin Kim   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Investing in transportation to keep Texas economically competitive : executive summary [PDF]

open access: yes
In 2008, Texas Transportation Commission Chair Deirdre Delisiappointed members of the original 2030 Committee. The initialcharge of this committee made up of experienced and respectedbusiness leaders was to provide an independent, authoritativeassessment
Texas. Transportation Commission
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