Results 141 to 150 of about 4,956,614 (325)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

Guidelines for the Use of Synthetic Fluid Dust Control Palliatives on Unpaved Roads [PDF]

open access: yes, 2017
The amount of small soil particles, dust, lost from typical unpaved roads to fugitive dust is staggering. A 1 km stretch of unpaved road can contribute over 2400 kg of dust to the atmosphere (4.2 ton/mile) in a typical 3-month summer season.
Barnes, David, Connor, Billy
core  

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Traffic flow prediction based on improved deep extreme learning machine

open access: yesScientific Reports
A new hybrid prediction model is proposed for short-term traffic flow, which is based on Deep Extreme Learning Machine improved by Sparrow Search Algorithm (SSA-DELM).
Xiujuan Tian   +5 more
doaj   +1 more source

Tracking Report 2011 Pou Chen, Indonesia 070033435J [PDF]

open access: yes, 2011
This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide.
Fair Labor Association
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

TRANSITIONING TO A LOW-CARBON IRISH ECONOMY: AN ANALYSIS OF REGIONAL LABOUR IMPACTS. RESEARCH SERIES NUMBER 100 December 2019 [PDF]

open access: yes, 2019
Ireland has legally binding emissions reduction targets for 2020 and 2030. To achieve these targets and to become a low-carbon economy, the government uses carbon taxation as one of the primary policy tools.
de Bruin, Kelly   +3 more
core  

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