Results 31 to 40 of about 104,820 (261)

Intein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast

Nature Communications
While sanguinarine has gained recognition for antimicrobial and antineoplastic activities, its complex conjugated structure and low abundance in plants impede broad applications.
Yuanwei Gou, Dongfang Li, Minghui Zhao, Mengxin Li, Jiaojiao Zhang, Yilian Zhou, Feng Xiao, Gaofei Liu, Haote Ding, Chenfan Sun, Cuifang Ye, Chang Dong, Jucan Gao, Di Gao, Zehua Bao, Lei Huang, Zhinan Xu, Jiazhang Lian   +17 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Chemical Transportation Risk Assessment in the pass leading to Amirkabir Terminal at Shiraz City

Salāmat-i kār-i Īrān, 2016
Background and aims: Transportation of hazardous chemicals is one of the main phases in chemical life cycle which could endanger the safety of people and facilities that are located in the tanker traffic roads. The aim of this study was to assess risk of
M Jahangiri, HR Jamshidi
doaj  

Intricate Metabolic Network for Paclitaxel Biosynthesis

BioDesign Research
Paclitaxel is a renowned broad-spectrum anticancer drug. With the establishment of a chromosome-level high-quality reference genome map of Taxus, recent research on paclitaxel biosynthesis has flourished. The oxetane ring is a distinctive chemical moiety
Yuanwei Gou, Xiaojing Jiang, Jiazhang Lian   +2 more
doaj   +1 more source

Network Marketing Path and Technical Safety Guarantee of Hazardous Articles in Chemical Enterprises under Internet + Environment

Chemical Engineering Transactions, 2018
Chemical dangerous goods such as CH2N2, HClO4, CO, and CH are mostly toxic, inflammable and explosive, and they are likely to cause harm to the human body and the environment.
Shengmin Xiong
doaj   +1 more source

Chemically Fueled Active Transport

Angewandte Chemie International Edition
Abstract Biology uses chemical potential differences from molecules like ATP to drive membrane pumps, transporting molecules across membranes even against concentration gradients. Here, we report a synthetic system that transports small molecules from an aqueous phase (the sender) to an aqueous receiver across a centimeter‐sized ...
Christine M. E. Kriebisch, Brigitte A. K. Kriebisch, Gregor Häfner, Héctor Soria‐Carrera, Yanyan Fei, Marcus Müller, Job Boekhoven   +6 more
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Effect of Fines Content on Fluidity of FCC Catalysts for Stable Operation of Fluid Catalytic Cracking Unit

Energies, 2019
Effect of fines content (weight % of particles with diameter less than 45 μm) on bed fluidity was determined to get a base for good fluidization quality in the fluid catalytic cracking (FCC) unit.
Sung Won Kim, Chae Eun Yeo, Do Yeon Lee   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source