Results 41 to 50 of about 104,820 (261)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Computational Fluid Dynamics Investigation of Filling Fuel Cell Electric Vehicle Hydrogen Storage Tanks According to Refueling Protocol Focused on Maximum Temperature Rise

Energies
Hydrogen refueling protocols such as SAE J2601 are designed to limit the temperature rise of hydrogen within the storage tank during refueling. However, the temperature distribution inside the tank is inherently non-uniform, and resulting thermal ...
Gyu Seok Shim, Hyo Min Seo, Joonho Kim, Byung Heung Park   +3 more
doaj   +1 more source

Chemical transport and zirconium [PDF]

Journal of Chemical Education, 1969
Draws attention to a recent paper that discusses the purification of zirconium by the Van Arkel filament method.
openaire   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Study on the design method of multi-component industrial solid waste low carbon cementitious material with cement as the activator

Case Studies in Construction Materials
The relationship between microstructure and mechanical properties of multi-component solid waste low-carbon cementitious materials has been widely pay attention to.
Ruiqi Wang, Guodong Li, Changyan Li, Yupeng Huo, Teng Wang, Peng Hou, Zuo Gong   +6 more
doaj   +1 more source

"Times are changing ... and so must we" Integral Logistics and Services for the World-Scale Producer in Switzerland

CHIMIA, 2005
The chemical distribution business has traditionally consisted of a more or less one-way flow of information and products channeled through the distributor's organization.
Erich Habegger, Georg Kirschbaum, Ivan Vollenweider   +2 more
doaj   +1 more source

Analysis of Hazardous Chemicals Transportation Accidents and Transportation Management

Chemical Engineering Transactions, 2018
The causes of hazardous chemicals transportation accidents include direct and indirect causes, among which the lack of management is an important one. Through structural equation modelling, this paper constructs a hypothetic relationship between management factors and direct influencing factors to hazardous chemicals transportation accidents, and ...
Zhang Xiaheng, Li Xiao
openaire   +2 more sources