Results 51 to 60 of about 6,195,681 (305)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

"Times are changing ... and so must we" Integral Logistics and Services for the World-Scale Producer in Switzerland

open access: yesCHIMIA, 2005
The chemical distribution business has traditionally consisted of a more or less one-way flow of information and products channeled through the distributor's organization.
Erich Habegger   +2 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Annual Report for Calendar Year 2017: New England Transportation Consortium [PDF]

open access: yes
The New England Transportation Consortium (NETC) is a cooperative effort of the transportation agencies of the six New England States, the six New England state land grant universities, and the Federal Highway Administration (FHWA).
New England Transportation Consortium
core  

Transportation Expressions

open access: yes
This report compiles definitions of transportation terms used throughout the Department of Transportation and other US government agencies. This is the first edition of Transportation Expressions; future editions will be expanded in scope to include ...
O'Leary, Pamela   +2 more
core   +1 more source

Analysis of Hazardous Chemicals Transportation Accidents and Transportation Management

open access: yesChemical Engineering Transactions, 2018
The causes of hazardous chemicals transportation accidents include direct and indirect causes, among which the lack of management is an important one. Through structural equation modelling, this paper constructs a hypothetic relationship between management factors and direct influencing factors to hazardous chemicals transportation accidents, and ...
Zhang Xiaheng, Li Xiao
openaire   +2 more sources

Study on the design method of multi-component industrial solid waste low carbon cementitious material with cement as the activator

open access: yesCase Studies in Construction Materials
The relationship between microstructure and mechanical properties of multi-component solid waste low-carbon cementitious materials has been widely pay attention to.
Ruiqi Wang   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

State Transportation Statistics 2014 [PDF]

open access: yes
The Bureau of Transportation Statistics (BTS) presents State Transportation Statistics 2014, a statistical profile of transportation in the 50 states and the District of Columbia.
Nguyen, Long X.   +1 more
core   +1 more source

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