Results 81 to 90 of about 531 (218)
Study of photometric and spectral variability of the roAp star HD 210684
Astronomy & AstrophysicsAims. This paper studies the photometric and spectropolarimetric variability of HD 210684 in order to derive its magnetic properties, rotational period, evolutionary stage, and global stellar parameters. Methods. We used the discrete Fourier transform to
Khalack V., Lovekin C.
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Li-rich Unevolved Stars from LAMOST-MRS
The Astrophysical JournalBased on the spectra from the Large Sky Area Multi-Object Fiber Spectroscopic Telescope medium-resolution spectroscopic survey, we select a sample of 88 Li-rich unevolved star candidates.
Ze-Ming Zhou +17 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Detection of Enhanced Germanium in a New Cool Extreme Helium Star A980: Insights and Implications
The Astrophysical JournalA fine abundance analysis of a recently discovered hydrogen-deficient carbon (HdC) star, A980, is presented. Based on the observed high-resolution optical spectrum, we ascertain that A980 is a cool extreme helium (EHe) star and not an HdC star.
Ajay Kumar Saini, Gajendra Pandey
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
A molecule perturbation software library and its application to study the effects of molecular design constraints. [PDF]
J Cheminform, 2023 Kerstjens A, De Winter H.
europepmc +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Discovery of a runaway star likely ejected by a Type Iax supernova
Astronomy & AstrophysicsOver the past decade, runaway stars believed to originate either as surviving donors of Type Ia supernovae or as partially deflagrated accretors producing Type Iax supernovae, have been identified. While the former have been extensively studied recently,
Bhat A. +7 more
doaj +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source