Results 61 to 70 of about 207,787 (293)

Harvesting the Promise of AOPs: An assessment and recommendations [PDF]

, 2018
The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals.
Ankley, Gerald T., Carusi, Annamaria, Davies, Mark R., De Grandis, Giovanni De, Escher, Beate I., Hodges, Geoff, Wheelan, Maurice, Willet, Catherine, Y. Leung, Kenneth M.   +8 more
core   +4 more sources

A miniaturized passive sampling-based workflow for monitoring chemicals of emerging concern in water

Science of The Total Environment, 2022
The miniaturization of a full workflow for identification and monitoring of contaminants of emerging concern (CECs) is presented. Firstly, successful development of a low-cost small 3D-printed passive sampler device (3D-PSD), based on a two-piece methacrylate housing that held up to five separate 9 mm disk sorbents, is discussed.
Richardson, Alexandra K., Irlam, Rachel C., Wright, Helena Rapp, Mills, Graham A., Fones, Gary R., Stürzenbaum, Stephen R., Cowan, David A., Neep, David J., Barron, Leon P.   +8 more
openaire   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Transgenerational inheritance of chemical-induced signature: A case study with simvastatin

Environment International, 2020
The hypothesis that exposure to certain environmental chemicals during early life stages may disrupt reproduction across multiple non-exposed generations has significant implications for understanding disease etiology and adverse outcomes. We demonstrate
T. Neuparth, A.M. Machado, R. Montes, R. Rodil, S. Barros, N. Alves, R. Ruivo, L. Filipe C. Castro, J.B. Quintana, M.M. Santos   +9 more
doaj   +1 more source

PikMe: a flexible prioritization tool for chemicals of emerging concern

Environmental Toxicology and Chemistry
Abstract Identifying new contaminants of emerging concern remains a complex task due to the sheer number of chemical substances potentially released into the environment, the scattered sources of information, and often the lack of adequate data. Environmental screening and monitoring programs are designed to map the presence, sources,
Aina Charlotte Wennberg, Pawel Rostkowski, Malcolm Reid   +2 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Maximizing the Security Benefits from the First Review Conference of the Chemical Weapons Convention [PDF]

, 2002
Ye
Pearson, Graham S.
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Nanotechnology Oversight: An Agenda for the New Administration [PDF]

, 2008
Identifies how current laws can be applied or modified to provide needed oversight of nanotechnology and materials for public health and environmental protection.
J. Clarence Davies
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source