Results 71 to 80 of about 207,787 (293)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Ecotoxicological Effects of Emerging Contaminants on Aquatic Species

Toxics
Emerging contaminants (ECs), also known as contaminants of emerging concern (CECs), are defined as synthetic or naturally occurring chemicals or biological agents that are not commonly monitored in the environment but have the potential to enter the ...
Thiago Lopes Rocha, Luís Manuel Félix, Davi Farias   +2 more
doaj   +1 more source

Visits: The emerging portfolio [PDF]

, 1999
Ye
Pearson, Graham S.
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Mathematical Study on Prey-Predator Dynamics Under Effect of Water Contamination [PDF]

BIO Web of Conferences
A significant class of water pollutants emerging as a threat to human and aquatic populations is Per-and-polyfluoroalkyl substances (PFAS). The primary concern linked to PFAS is that they exhibit bioaccumulation potential as their perfluorocarbon ...
Tangri Shreya, Kumari Ruby, Kalra Preety
doaj   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Bioremediation of Synthetic Wastewater with Contaminants of Emerging Concern by Nannochloropsis sp. and Lipid Production: A Circular Approach

Bioengineering
Contaminants of emerging concern (CECs) pose a potential risk to human and environmental health. Microalgae bioremediation is a promising approach for transforming or removing contaminants from the environment, while contributing to the circular economy.
Bruna Santos, Juliana Araújo, Beatriz Carvalho, Carolina Cotrim, Raul Bernardino, Filomena Freitas, Abílio J. F. N. Sobral, Telma Encarnação   +7 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Identifying and Prioritizing Chemicals with Uncertain Burden of Exposure: Opportunities for Biomonitoring and Health-Related Research. [PDF]

, 2019
BackgroundThe National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the impact of environmental factors on childhood disease. Over 40,000 chemicals are approved for commercial use.
(Environmental influences on Child Health Outcomes), Beamer, Paloma I, Bennett, Deborah H, Boyles, Rebecca R, Buckley, Jessie P, Kannan, Kurunthachalam, Pellizzari, Edo D, Wang, Aolin, Woodruff, Tracey J, Zhu, Yeyi   +9 more
core  

Contamination [PDF]

, 2011
Soil contamination occurs when substances are added to soil, resulting in increases in concentrations above background or reference levels. Pollution may follow from contamination when contaminants are present in amounts that are detrimental to soil ...
Bacon, J., Cundill, A., Dale, P., Fordyce, F.M., Fowler, D., Hedmark, A., Hern, A., Skiba, U.   +7 more
core   +1 more source