Results 191 to 200 of about 139,194 (301)

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Circulating 25-Hydroxy-Vitamin D Levels in Menopausal and Postmenopausal Women in Italy: A Comparison of Four Analytical Methods. [PDF]

Diseases
Tomassetti F, Pelagalli M, Cortese F, Giovannelli A, Carloni EM, Morello M, Nicolai E, Terrinoni A, Pieri M, Bernardini S.   +9 more
europepmc   +1 more source

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

Machine learning-assisted paper-based chemiluminescence biosensor for choline quantification in infant milk: toward portable nutritional quality monitoring. [PDF]

Sci Rep
Zalke JB, Kaushik V, Singhal CM, Kulkarni MB, Bhaiyya M.   +4 more
europepmc   +1 more source

A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Advanced Science, EarlyView.
A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao, Yufei Lan, Min‐Goo Lee, Jinjun He, Yueran Pan, Eunji Kim, Xin Fu, Sungwook Jung, Wanxia Lu, Jinyue Fan, Haoxiang Chen, Yuanbo Zhao, Yuling Xu, Jong Seung Kim, Chao Zhang   +14 more
wiley   +1 more source

Acridinium Chemiluminogenic Labels-Synthesis, Analytical Performance, and Mechanism of Light Generation-A Comparison in View of Biomedical Diagnostics. [PDF]

Molecules
Krzymiński K, Zadykowicz B, Czechowska J, Rudnicki-Velasquez P, Serdiuk I, Sieradzan AK, Holec-Gąsior L.   +6 more
europepmc   +1 more source

Development and validation of a chemiluminescent immunoassay platform for rapid detection of lymphocytic choriomeningitis virus antibodies [PDF]

Antoine Dubois-Laurent
openalex   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

Prussian blue-supported platinum nanoparticles as pH-Universal catalase mimics: enabling robust chemiluminescent immunoassay for VEGF in clinical diagnostics. [PDF]

Front Bioeng Biotechnol
Yang Y, Li J, Hu X, Xiu Y, Zhang M, Wang C, Liu X, Liang B, Xing D, Zhang T.   +9 more
europepmc   +1 more source