Results 11 to 20 of about 2,300,404 (265)
High-Pressure Mechanistic Insight into Bioinorganic NO Chemistry [PDF]
, 2021 Pressure is one of the most important parameters controlling the kinetics of chemical reactions. The ability to combine high-pressure techniques with time-resolved spectroscopy has provided a powerful tool in the study of reaction mechanisms. This review
van Eldik, Rudi +11 more
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Bioinorganic Chemistry of Micronutrients Related to Alzheimer's and Parkinson's Diseases [PDF]
, 2023 : Metal ions are fundamental to guarantee the regular physiological activity of the human organism. Similarly, vitamins play a key role in many biological functions of the metabolism, among which are coenzymes, redox mediators, and antioxidants.
Valensin, Daniela +5 more
core +1 more source
Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs [PDF]
, 2009 This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging.
Rijt, Sabine H. van, Sadler, P. J.
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Angewandte Chemie, EarlyView.Clade B carbon monoxide dehydrogenases (CODHs) remain enigmatic, diverging from canonical CODHs in structure and function. Here, we present the first characterization of Ruminococcus flavefaciens CODH (RfCODH), revealing occluded substrate pathways and attenuated CO oxidation activity.
Maximilian Böhm +6 more
wiley +2 more sources
A Conserved Isoleucine Gates the Diffusion of CO and O2 to the Active Site of NiFe CO‐Dehydrogenase
Angewandte Chemie, EarlyView.A combination of protein film electrochemistry and site‐directed mutagenesis shows that isoleucine 563 (numbering of Thermococcus sp. AM4) gates the arrival of both CO and O2 to the active site of the nickel‐iron CO dehydrogenases. Mutations at this position increase the resistance to O2 at the cost of a slower reaction with CO.
Laura Opdam +7 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Cancer stem cells (CSCs) drive metastasis, relapse and resist conventional apoptosis‐inducing chemotherapies. We report a cobalt(III)‐cyclam complex with pyrene and diflunisal moieties that reduces the viability of breast CSCs at low micromolar concentrations.
Jiaxin Fang +7 more
wiley +2 more sources
Computer applications in bioinorganic chemistry [PDF]
, 2018 Nowadays, computers play an indispensable role in the determination of metal-ligand formation constants and in their application to various situations of analytical, industrial or biological interest. The development of programs and simulation techniques
May, Peter Michael
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Advanced Science, EarlyView.Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green +15 more
wiley +1 more source
Interactions of trivalent lanthanide cations with a new hexadentate di-Schiff base : new lanthanide(III) complexes from (NE,N ' E)-2,2 '-(ethane-1,2-diylbis(oxy))bis(N-(pyridin-2-ylmethylene)ethanamine) [PDF]
, 2010 This research was cofunded by the European Union in the framework of the program “Heraklitos” of the “Operational Program for Education and Initial Vocational Training” of the 3rd Community Support Framework of the Hellenic Ministry of Education, funded ...
Konstantina Skorda +11 more
core +1 more source