Results 11 to 20 of about 5,856 (239)

Copper(II/III) Redox Couple Enables C─H Methylation via a Radical Mechanism Analogous to SAM Enzymes

Angewandte Chemie, EarlyView.
Biological C–H methylation proceeds through radical pathways mediated by one‐electron redox cofactors, yet no synthetic model has reproduced this reactivity. Here, we report the first isolable Cu(II/III)–methyl complexes that mediate C–H methylation through hydrogen atom transfer and methyl radical rebound.
Emily N. Doss, Curtis E. Moore, Shiyu Zhang   +2 more
wiley   +2 more sources

Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds (r‐mS): A Platform for Metallodrug Discovery

Angewandte Chemie, EarlyView.
Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters, Harry Wilders, George S. Biggs, Mika Kintzel, Emma E. Cawood, Jonathan Bailey, Sarah Maslen, Yew Mun Yip, Mason Wakley, Ioannis G. Riziotis, Thomas W. Rees, Joanna Redmond, J. Mark Skehel, David House, Jacob Bush, Jeannine Hess   +15 more
wiley   +2 more sources

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Mechanistic Understanding of Protein–MOF Integration Through Surfactant‐Driven Interfacial Design

Advanced Science, EarlyView.
This study reveals how surfactant‐driven interfacial design governs the assembly and stability of protein@MOF composites. Using lipid‐based nonionic surfactants, we modulate protein–MOF interactions to improve encapsulation efficiency, MOF crystallization, and catalytic performance.
Ehsan Rashidniyaghi, Mohammad Khavani, Carlie Coerver, Ruibin Liang, Raheleh Ravanfar   +4 more
wiley   +1 more source

Gold(I) Phosphine/Phosphido‐Borohydride Complexes

European Journal of Inorganic Chemistry, EarlyView.
Synthesis, structure, and electrochemical characteristics of a homologous series of gold(I) complexes featuring phosphine and phosphido–borohydride ligands. A homologous series of linear, mononuclear gold(I) phosphine/phosphido‐borohydride complexes, encompassing [Au(PR3)2]+ 1, [Au(PR3)(PR2BH3)] 2 and [Au(PR2BH3)2]– 3 (R = tBu, Ad), has been prepared ...
Matthew J. G. Sinclair, Marc‐Etienne Moret, Luke A. Wilkinson, Adrian B. Chaplin   +3 more
wiley   +1 more source

On Oxalyl Halide Isothiocyanates Part II: Decarbonylation and Reactivity Studies

European Journal of Inorganic Chemistry, EarlyView.
Thermal decarbonylation of oxalyl halide isothiocyanates affords the respective carbonyl halide isothiocyanates as liquids. Crystals grown from melt allowed the elucidation of their crystal structures. Spectroscopic signatures (IR, Raman, NMR) are presented alongside reactivity studies. The reaction of oxalyl halide isothiocyanate, X(CO)2NCS (X = Cl (1)
Sven Ringelband, Frank Tambornino
wiley   +1 more source

On Oxalyl Halide Isothiocyanates Part I: Syntheses and Isomerism

European Journal of Inorganic Chemistry, EarlyView.
Oxalyl halide isothiocyanates can be prepared from oxalyl halide with one equivalent of NH4SCN in liquid SO2. While oxalyl bromide isothiocyanate can be isolated as a liquid, the respective chloride compound readily undergoes isomerization under formation of a thiazole ring, which is obtained as a solid.
Sven Ringelband, Jonathan Pfeiffer, Frank Tambornino   +2 more
wiley   +1 more source

Hydrosilane Chemistry: From Historic First Steps to Modern Applications

European Journal of Inorganic Chemistry, EarlyView.
This review covers the history of hydrosilanes, from their initial discovery to their modern applications. It highlights the pioneering work of chemists like Alfred Stock and Franz Fehér and discusses the modern ways of synthesis and use of hydrosilanes in printed electronics.
Uwe Böhme, Maik Gerwig
wiley   +1 more source

Dilithium Enediamide Derived From 1,4‐Diaza‐1,3‐Diene: An Electron Reservoir Enabling Variable Reactivity Toward Carbonyl Compounds

European Journal of Inorganic Chemistry, EarlyView.
Upon reduction of 1,4‐diaza‐1,3‐diene 1 to the dilithium enediamide 2, the polarity of the C = N bonds is reversed ‐ a classic case of umpolung. This behavior is particularly evident in reactions of the dianion 2 with carbonyl compounds and also explains why 1,4‐diaza‐1,3‐diene ligands do not always act merely as spectator ligands. 1,4‐Diaza‐1,3‐dienes
Muhan Liang, Michael Kunze, Helmar Görls, Joachim Scholz   +3 more
wiley   +1 more source

Carbon Dioxide Insertion by a Methylene‐Bridged Ga/P FLP

European Journal of Inorganic Chemistry, EarlyView.
In a salt elimination of Bis2GaBr (Bis = CH(SiMe3)2) with LiCH2PtBu2 the Bis2Ga–CH2–PtBu2 frustrated Lewis pairs is afforded. While forming usual 1,2‐adducts with cis‐azobenzene, CS2 and CO2, the latter shows an exceptional insertion when heated to 70°C, leading to a gallium carboxylate.
Julian Buth, Beate Neumann, Jan‐Hendrik Lamm, Yury V. Vishnevskiy, Norbert W. Mitzel   +4 more
wiley   +1 more source