Results 91 to 100 of about 4,155,826 (338)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Investigation of the Uniformity of Gel Shrinkage by Imaging Tracer Particles Using X‐Ray Microtomography

Advanced Engineering Materials, EarlyView., 2023
A novel method for tracking structural changes in gels using widely accessible microcomputed tomography is presented and validated for various hydro‐, alco‐, and aerogels. The core idea of the method is to track positions of micrometer‐sized tracer particles entrapped in the gel and relate them to the density of the gel network.
Anja Hajnal, Mimololorun Lucy Aiyelari, Martin Dirauf, Pavel Gurikov   +3 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Diastereoselective [Cu(MeCN)4BF4/BF3·Et2O]-Catalyzed Cyclopropenation of Alkynes: Asymmetric Synthesis of β-Amino-α-cyclopropenyl Phosphonates

SynOpen, 2017
The diastereospecific formation of β-amino-α-cyclopropenyl phosphonates has been achieved in moderate yields from the cyclopropenation of 1-alkynes with dialkyl α-diazophosphonates. The reaction was performed by using a combined catalyst consisting of Cu(
Haihong Ge, Shuang Liu, Yan Cai, Zenghui Gao, Siyi Du, Zhiwei Miao, Guixian Xie   +6 more
doaj   +1 more source

The chemistry and use of cellulose derivatives for the study of biological systems [PDF]

Cellulose chemistry and applications as carrier for proteins, polymers, and organic ...
Weetall, H. H., Weliky, N.
core   +1 more source

A Review on the Bulk and Surface Chemistry of Iron in Atmospherically-relevant Systems Containing Humic Like Substances (HULIS) [PDF]

, 2015
As the fourth most abundant element by mass in the Earth’s crust, iron is ubiquitous and its chemistry is rich and interdisciplinary in nature. This review synthesizes the current state of knowledge of iron chemistry in multicomponent atmospheric ...
Al-Abadleh, Hind A.
core   +1 more source

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Increasing International Awareness in the Organic Chemistry Laboratory [PDF]

, 2019
Undergraduate ...
Fulmer, Sierrah
core   +1 more source

Machine Learning, Quantum Mechanics, and Chemical Compound Space

, 2016
We review recent studies dealing with the generation of machine learning models of molecular and solid properties. The models are trained and validated using standard quantum chemistry results obtained for organic molecules and materials selected from ...
Adamo, Arsenault, Balabin, Baldi, Bartók, Behler, Behler, Bereau, Bereau, Botu, Botu, Büttiker, Caccin, Curtiss, Dobson, Dral, Dral, Drwal, Faber, Faber, Faulon, Feynman, Fisher, Frisch, Furche, Ghasemi, Ghiringhelli, Golbraikh, Grimme, Hammett, Hammett, Hansen, Hansen, Hansen, Harvey, Hastie, Helgaker, Ho, Hoffmann, Hu, Huan, Hättig, Ivanciuc, Jensen, Karthikeyan, Kayala, Kirkpatrick, Kohn, Kubinyi, Landauer, Landauer, Li, Lipinski, Lopez-Bezanilla, Lorenz, Lusci, Manzhos, Manzhos, Meredig, Misra, Montavon, Montavon, Moussa, Müller, Nørskov, Parr, Perdew, Perdew, Pettifor, Pilania, Popelier, Prodan, Pyykko, Pyzer-Knapp, Ramakrishnan, Ramakrishnan, Ramakrishnan, Ramakrishnan, Ramakrishnan, Rappé, Rasmussen, Ruddigkeit, Rupp, Rupp, Rupp, Rupp, Sadowski, Schatz, Schneider, Schölkopf, Schütt, Snyder, Stevens, Stewart, Stewart, Sumpter, Tikhonov, Todeschini, Tuckerman, van Duin, von Lilienfeld, von Lilienfeld, Wagner, Weigend, Yanai, Zheng, Álvarez-Moreno   +106 more
core   +1 more source