Results 101 to 110 of about 3,535,364 (294)

Influence of atomic bonds on the properties of the laxative drug sodium picosulphate

Heliyon, 2016
In this work, the influence of the different S═O, S−O, N⋯H, O⋯H, Na⋯O bonds present in the structures of the powerful laxative drug, sodium picosulphate in gas and aqueous solution phases were studied combining the density functional theory (DFT ...
Davide Romani, Isabel Salas Tonello, Silvia Antonia Brandán   +2 more
doaj   +1 more source

The Pharmaceutical Biochemistry Group: Where Pharmaceutical Chemistry Meets Biology and Drug Delivery [PDF]

, 2012
Successful drug discovery and development of new therapeutics is a long, expensive multidisciplinary process needing innovation and the integration of smart cutting edge science and technology to overcome the challenges in taking a drug from the bench to
Perozzo, Remo, Kalia, Yogeshvar N., Kalia, Yogeshvar, Scapozza, Leonardo, Scapozza L, Kalia YN, Perozzo R   +6 more
core   +1 more source

Design and evaluation of FEBS Education and Training Academy module – Integrating generative artificial intelligence into life‐science education

FEBS Open Bio, EarlyView.
Life‐science educators from 14 countries redesigned their own course materials with generative AI in a three‐session, pedagogy‐first FEBS Education and Training Academy workshop built on PICRAT. Among 12 matched respondents, four more reported high confidence in each of five practical domains, and 10 of 13 reported implementing at least one idea ...
Zvonimir Mlinarić, Ali Burak Özkaya
wiley   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source

Chemistry and Health: A Multidimensional Approach

Sustainable Chemistry
This review explores both the positive and negative impacts of chemistry on society, focusing on the intersection between pharmaceutical, natural, and synthetic chemicals.
Alcione S. de Carvalho, Iva S. de Jesus, Patrícia G. Ferreira, Acácio S. de Souza, Rafael P. R. F. de Oliveira, Debora O. Futuro, Vitor Francisco Ferreira   +6 more
doaj   +1 more source

Advances in Organic, Bioorganic and Pharmaceutical Chemistry. 40. Conference

, 2005
Latest results in the fields of organic, bioorganic, and pharmaceutical chemistry obtained in the Czech Republic were summarized on the ...
Valterová, Irena
core  

Real‐World Safety of Concomitant Colchicine and Statin Therapy

Arthritis Care &Research, EarlyView.
Objective This study aimed to evaluate the risk of clinically meaningful muscle‐ and liver‐related outcomes associated with concomitant colchicine–statin therapy in a real‐world setting, and to determine whether concomitant therapy increases the incidence of toxicity compared with either agent alone.
Roni Meidan, Ranel Loutati, Dan Caspi, Ori Elkayam, Ran Abuhasira, Tali Eviatar   +5 more
wiley   +1 more source

The chemistry and sources of fructose and their effect on its utility and health implications [PDF]

, 2016
Fructose is a significant component in unprocessed food and has become one of the most commonly sweeteners used in food manufacturing. Fructose is also a useful pharmaceutical excipient and derivatives of fructose are exploited as renewable chemical ...
Peter D. Cooper, Nikolai Petrovsky, Milena Ginic-Markovic, Thomas Barclay   +3 more
core  

Effect of Calendering and Surface Treatment on the Thermochromic Response of Cholesteric Liquid Crystals on PET Nonwovens

Advanced Engineering Materials, EarlyView.
This study explores the influences of calendering and surface treatment during direct ink writing (DIW) of thermochromic cholesteric liquid crystal (CLC) on PET nonwovens. For the PVA‐coated nonwovens, calendering reduces pore size leading to reduced ink absorption and enhanced spreading. The NeverWet‐coated nonwovens improve thermochromic responses by
Sreenivasan Sreenivasan Narayanan, Lineth Pérez Monsalve, Christina Tang, Hong Zhao   +3 more
wiley   +1 more source