Reihs et al. present the development of a humanized, animal‐free synovial membrane model for osteoarthritis. Methods include 3D biochip cultures of human‐primary OA synoviocytes with matrix and serum surrogates. Results show replication of synovial architecture and increased Yap1 expression.
Eva I. Reihs+17 more
wiley +1 more source
Correction: TAK1 inhibition by natural cyclopeptide RA-V promotes apoptosis and inhibits protective autophagy in Kras-dependent non-small-cell lung carcinoma cells. [PDF]
Yang J+9 more
europepmc +1 more source
Colon‐Targeted Natural Polysaccharide‐Berberine Armored Hydrogel for the Treatment of Colitis
In this research, a novel hydrogel system targeting the colon is developed, incorporating Rhubarb polysaccharides and berberine‐loaded dendrimer. This hydrogel, forms through intermolecular hydrogen bonding and electrostatic interactions, accumulates in colonic tissues, effectively alleviating pathological immune hyperactivation while modulating gut ...
Miao Guo+8 more
wiley +1 more source
Revolutionizing organic synthesis through green chemistry: metal-free, bio-based, and microwave-assisted methods. [PDF]
Banerjee S+4 more
europepmc +1 more source
Advanced Oral Delivery Systems for Nutraceuticals
Emerging delivery technologies are explored to overcome barriers to oral nutraceutical absorption. Traditional carriers are compared with novel platforms including biodegradable polymers, MOFs, MPNs, and 3D printing. These systems enhance bioavailability, control release, and enable personalized nutrition.
Xin Yang+4 more
wiley +1 more source
Computer aided greenness by design approach for resolving and quantifying Triamterene and Hydrochlorothiazide in pharmaceutical mixtures employing multiscale dynamics simulations. [PDF]
Elsonbaty A, Attala K, Darweish E.
europepmc +1 more source
Comparison of two pharmaceutical production processes using different eco-efficiency measuring methods [PDF]
Aelterman, Wim+7 more
core +1 more source
An RBC membrane camouflaged, cell‐penetrating peptides R8‐based drug delivery system is constructed to achieve a synergistic combination of natural compounds triptolide (TP) and celastrol (Cel), inducing tumor cell apoptosis, reducing tumor metastasis invasion and triggering autophagy disorder in breast cancer and liver cancer.
Qian Cheng+6 more
wiley +1 more source
A sustainable multi-task HPLC-UV method for simultaneous analysis of top neuromodulating agents in diverse pharmaceutical formulations. [PDF]
El-Hanboushy S, M Marzouk H, S Ayish N.
europepmc +1 more source