Results 141 to 150 of about 225,258 (237)

Introducing Pure Calcium Orthophosphate Gels and Aerogels

Advanced Functional Materials, EarlyView.
The synthesis of calcium phosphate‐based gels and aerogels is reported, which exhibit highly porous structures built up of networks of nanoparticles. In case of amorphous aerogels, this leads to yet unmatched specific BET surface areas, making these materials especially interesting for biomedical applications.
Oliver Jeske, Dominik Zanker, Nina Ehlert, Bing‐Qiang Lu, Denis Gebauer   +4 more
wiley   +1 more source

Solvent Sustainability in Drug Discovery: Where Are We Now, and How Can We Improve? [PDF]

J Med Chem
Richardson P, Bryan MC, Diorazio L, Gallou F, Keily S, Martinez I, Plummer S, Reed AB, Sheppard R, Shields J, Wrigley G, Yeung C, Enríquez-García Á.   +12 more
europepmc   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Correction: Multi-step organic synthesis, cytotoxicity, and molecular docking of new N-phenylpyrazolones incorporated with N-benzylthiazole or N-benzyl-4-thiazolone fragments. [PDF]

Sci Rep
Ahmed AA, El-All MMA, El-Hallouty SM, Elshahid ZA, Eliwa EM.   +4 more
europepmc   +1 more source

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

A fluorescence-off based approach for sensitive determination of bepotastine in pharmaceutical and biological matrices considering human safety aspects: sustainability assessment. [PDF]

Sci Rep
Al-Farhan BS, Ali MAM, Chaudhary AA, Saleh SF, Ibrahim AMM, Obaydo RH, Hamad AA.   +6 more
europepmc   +1 more source

High‐Resolution Characterization of Protein‐Conjugated, mRNA‐Loaded Lipid Nanoparticles by Analytical Ultracentrifugation

Advanced Functional Materials, EarlyView.
Lipid nanoparticles containing messenger RNA are characterized by sedimentation velocity analytical ultracentrifugation using UltraScan's new Custom Grid algorithm to provide multi‐dimensional distributions for partial specific volume (particle density), molar mass, sedimentation, diffusion, and hydrodynamic radius.
Sophia Bird, Connor Smith, Nahal Habibi, Samantha Rivera, Saeed Mortezazadeh, Reece Martin, Benjamin M. Geilich, Gilles Besin, Borries Demeler   +8 more
wiley   +1 more source

Employing intrinsic fluorone-dye fluorescence in a quenching-based ("on-off") strategy for diltiazem determination in tablets and capsules. [PDF]

BMC Chem
Abu-Hassan AA.
europepmc   +1 more source

Proteins, Processing, and Properties of Adhesive Fluid Condensates Purified from Mussels

Advanced Functional Materials, EarlyView.
Mussels exhibit an unmatched proficiency for adhering to wet surfaces in salty environments—a remarkable ability that could inspire new biomedical and technical glues. The fluid protein condensates used to form the underwater mussel glue are extracted, reconstituted and characterized with advanced spectroscopy and nanomechanical analysis, revealing ...
Mathieu D. Rivard, Max Renner‐Rao, Nahid Hassanpour, Franziska Jehle, Chang‐Sheng Wang, Duy Anh Pham, Daniel J. Jackson, Xavier Banquy, Matthew J. Harrington   +8 more
wiley   +1 more source

Correction: Harmine derivative B-9-3 inhibits non-small cell lung cancer via the VEGFA/PI3K/AKT pathway. [PDF]

Front Pharmacol
Wu Y, Wang B, Mao X, Chen W, Aisa HA.
europepmc   +1 more source