Results 11 to 20 of about 555,640 (280)

Design, synthesis, biological evaluation and molecular docking studies of novel 3-substituted-5-[(indol-3-yl)methylene]-thiazolidine-2,4-dione derivatives

Heliyon, 2018
Various thiazolidine-2,4-dione derivatives 3a-l possessing indole moiety were designed, synthesized using appropriate conventional heating as well as microwave irradiation methods.
K. Srikanth Kumar, A. Lakshmana Rao, M.V. Basaveswara Rao   +2 more
doaj   +1 more source

QSAR study of anti-Human African Trypanosomiasis activity for 2-phenylimidazopyridines derivatives using DFT and Lipinski's descriptors

Heliyon, 2019
The quantitative structure-activity relationship (QSAR) of sixty 2-phenylimidazopyridines derivatives with anti-Human African Trypanosomiasis (anti-HAT) activity has been studied by using the density functional theory (DFT) and statistical methods. Becke'
Samir Chtita, Mounir Ghamali, Abdellah Ousaa, Adnane Aouidate, Assia Belhassan, Abdelali Idrissi Taourati, Vijay Hariram Masand, Mohammed Bouachrine, Tahar Lakhlifi   +8 more
doaj   +1 more source

Polyethylene glycol (PEG) decorated graphene oxide nanosheets for controlled release curcumin delivery

Heliyon, 2019
Nowadays, the use of nanostructures in various medical and biological fields such as drug delivery in cancer treatment is increasing. Among the nanostructures, graphene oxide (GO) is an excellent candidate for drug delivery application because of its ...
Jalil Charmi, Hamed Nosrati, Jafar Mostafavi Amjad, Ramin Mohammadkhani, Hosein Danafar   +4 more
doaj   +1 more source

Optimization of tris(2-carboxyethyl) phosphine reduction conditions for fast analysis of total biothiols in mouse serum samples

Heliyon, 2019
In this study, we investigated suitable conditions for the reduction of disulfides in mouse serum samples by tris(2-carboxyethyl) phosphine (TCEP) for fast analysis of total biothiols.
Chunfang Chang, Muneki Isokawa, Takashi Funatsu, Makoto Tsunoda   +3 more
doaj   +1 more source

A user-friendly Matlab program and GUI for the pseudorotation analysis of saturated five-membered ring systems based on scalar coupling constants [PDF]

, 2008
Background: The advent of combinatorial chemistry has revived the interest in five-membered heterocyclic rings as scaffolds in pharmaceutical research. They are also the target of modifications in nucleic acid chemistry.
Hendrickx, Pieter, Martins, José
core   +4 more sources

Synthesis and biological activity of fused tetracyclic Pyrrolo[2,1-c][1,4]benzodiazepines

Heliyon, 2018
Cancer remains the second major cause of death in the world. Thus, there is a pressing need to identify potential synthetic route for the development of novel anticancer agents which will serve as lead compounds to effectively combat this life ...
Joel K. Annor-Gyamfi, John M. Jarrett, Joseph O. Osazee, Dobrusia Bialonska, Crystal Whitted, Victoria E. Palau, Abbas G. Shilabin   +6 more
doaj   +1 more source

Development of a validated RP-HPLC/DAD method for the quantitative determination of methyl jasmonate in an insect repellent semi-solid formulation

Heliyon, 2019
A simple and efficient reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the first time for the estimation of a mosquito repellent, methyl jasmonate in a cream formulation, and validated as per the ...
Johirul Islam, Saurav Phukan, Pronobesh Chattopadhyay   +2 more
doaj   +1 more source

New spectral resolution techniques for resolving and determining the components in binary fixed-dose combinations

Heliyon, 2019
Four spectrophotometric approaches were performed to determine a binary combination of Phenazone and Benzocaine in pure powder form and in pharmaceutical formations. This investigation submits the application of four techniques contingent on the presence
Duaa J. Al Zakri, Reem H. Obaydo, Amir Alhaj Sakur   +2 more
doaj   +1 more source

Development and validation of eco-friendly micellar-HPLC and HPTLC-densitometry methods for the simultaneous determination of paritaprevir, ritonavir and ombitasvir in pharmaceutical dosage forms

Heliyon, 2019
Ombitasvir, ritonavir and paritaprevir are three recently discovered directly acting antiviral drugs (DAADs) used in combined single dose tablet dosage form for treatment of hepatitis-C viral infections (HCV).
Adel Ehab Ibrahim, Roshdy E. Saraya, Hanaa Saleh, Magda Elhenawee   +3 more
doaj   +1 more source

Voltammetric determination of paracetamol in tablet formulation using Fe (III) doped zeolite-graphite composite modified GCE

Heliyon, 2019
Although paracetamol is known to have excellent safety profile at recommended therapeutic doses, health effects are also reported at acute overdoses.
Meareg Amare
doaj   +1 more source