Results 21 to 30 of about 1,899,138 (288)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A relationship between electron transfer rates and molecular conduction

open access: yes, 2001
This note discusses the relationship between a given intramolecular bridge assisted electron transfer rate and the corresponding zero bias molecular conduction of the same molecular species.Comment: 7 pages.
Nitzan, A.
core   +1 more source

Why Are There So Few Women in Physics? Reflections on the Experiences of Two Women

open access: yes, 2020
Some of the reasons for the underrepresentation of women in physics are evident in the reflections of two undergraduate women. Leia is a chemistry major who loves college-level physical chemistry and quantum mechanics but does not identify with the ...
Doucette, Danny, Singh, Chandralekha
core   +1 more source

Simulation of Heme using DFT+U: a step toward accurate spin-state energetics [PDF]

open access: yes, 2007
We investigate the DFT+U approach as a viable solution to describe the low-lying states of ligated and unligated iron heme complexes. Besides their central role in organometallic chemistry, these compounds represent a paradigmatic case where LDA, GGA ...
Cococcioni, Matteo   +3 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Physical Chemistry

open access: yes, 2023
Many pharmaceutical dosage forms are liquids or semi-liquids such as solutions, colloidal systems, suspensions and emulsions. This chapter deals with the physico-chemical backgrounds that are important for the preparation of these types of dosage forms.
Hinrichs, Wouter, van Gestel, Renske
openaire   +4 more sources

Warm Cores around Regions of Low-Mass Star Formation

open access: yes, 2010
Warm cores (or hot corinos) around low-mass protostellar objects show a rich chemistry with strong spatial variations. This chemistry is generally attributed to the sublimation of icy mantles on dust grains initiated by the warming effect of the stellar ...
André   +39 more
core   +1 more source

The Polytropic Equation of State of Interstellar Gas Clouds [PDF]

open access: yes, 2000
Models are presented for the polytropic equation of state of self-gravitating, quiescent interstellar gas clouds. A detailed analysis, including chemistry, thermal balance, and radiative transfer, is performed for the physical state of the gas as a ...
de Jong T.   +8 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

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