Results 31 to 40 of about 1,899,138 (288)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Organic compounds generated after the flow of water through micro-orifices: Were they synthesized?

Heliyon, 2017
Micro-fluid mechanics is an important area of research in modern fluid mechanics because of its many potential industrial and biological applications. However, the field is not fully understood yet. In previous work, when passing ultrapure water (UPW) in
Tomiichi Hasegawa, Akiomi Ushida, Masaki Goda, Yasushi Ono   +3 more
doaj   +1 more source

Simply conceiving the Arrhenius law and absolute kinetic constants using the geometric distribution

, 2013
Although first-order rate constants are basic ingredients of physical chemistry, biochemistry and systems modeling, their innermost nature is derived from complex physical chemistry mechanisms.
Michel, Denis
core   +3 more sources

Identifying (BN)2-pyrene as a new class of singlet fission chromophores: significance of azaborine substitution [PDF]

, 2018
Singlet fission converts one photoexcited singlet state to two triplet excited states and raises photoelectric conversion efficiency in photovoltaic devices.
Mellerup, Soren, Stamplecoskie, Kevin, Wang, Suning, Wang, Xiang, Yang, Dengtao, Zeng, Tao   +5 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Detailed chemical characterization and molecular modeling of serotonin inclusion complex with unmodified β-cyclodextrin

Heliyon, 2019
In this study, we analyzed the capability of unmodified β-cyclodextrin (β-CD) to form the stable complex with serotonin hydrochloride (SER), as an important neurotransmitter in the brain.
F. Fateminasab, A.K. Bordbar, S. Shityakov   +2 more
doaj   +1 more source

Beyond the pseudo-time-dependent approach: chemical models of dense core precursors

, 2010
Context: Chemical models of dense cloud cores often utilize the so-called pseudo-time-dependent approximation, in which the physical conditions are held fixed and uniform as the chemistry occurs.
Bergin, Bergin, Burgh, Chang, Crutcher, Cuppen, Draine, Draine, Draine, E. A. Bergin, E. Herbst, Fournier, Frerking, G. E. Hassel, Garrod, Garrod, Garrod, Gredel, Grim, Hartmann, Hasegawa, Le Petit, Lee, Liszt, Liszt, McKee, Mitchell, Murakawa, Nejad, Nguyen, Nummelin, Ormel, Pineau des Forêts, Rachford, Reach, Roser, Ruffle, Sheffer, Sonnentrucker, Teixeira, Tielens, Whittet, Whittet, Whittet, Whittet, Zucconi, Öberg, Öberg, Öberg   +48 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Analisis bahan bakar Alternatif Komposit Biobriket dari Eceng gondok dengan Perekat Kotoran Sapi

Αl-Kimiya: Jurnal Ilmu Kimia dan Terapan, 2020
Energi terbarukan merupakan energi alternatif yang menjadi isu energi teratas, mengingat menipisnya persediaan bahan bakar bumi (tak terbarukan). Biomassa adalah adalah energi alternatif  yang menarik untuk dikembangkan saat ini, terutama di Indonesia ...
Lisa Adhani, Mutia Annisa Marsya, Saras Oktavia, Ika Irma Sindiany   +3 more
doaj   +1 more source

Extracting physical chemistry from mechanics: a new approach to investigate DNA interactions with drugs and proteins in single molecule experiments

, 2015
In this review we focus on the idea of establishing connections between the mechanical properties of DNAligand complexes and the physical chemistry of DNA-ligand interactions.
Rocha, M. S.
core   +1 more source