Results 41 to 50 of about 508,283 (258)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Formation of dendrimer-guest complexes as a strategy to increase the solubility of a phenazine N, N′-dioxide derivative with antitumor activity

Heliyon, 2019
Poly(amidoamine) and Poly(propylenimine) dendrimers with different generations and peripheral groups were studied as solubility enhancers and nanocarriers for 7-bromo-2-hydroxy-phenazine N5,N10-dioxide.
Nahir Dib, Luciana Fernández, Marisa Santo, Luis Otero, Fabrisio Alustiza, Ana Cecilia Liaudat, Pablo Bosch, M. Laura Lavaggi, Hugo Cerecetto, Mercedes González   +9 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Determination of optimal conditions for electrodeposition of Tin(II) in the presence of Alizarin Red S

Heliyon, 2016
A detailed physicochemical properties of aqueous solutions of alizarin red S − tin (II) chloride, has been thoroughly investigated by extensively exploring the effect of pH, concentration and temperature on the optimal conditions for the formation of tin
Nour Mohammad-Sadik Ali, Prince Nana Amaniampong, Ayman Karam   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Study on surface properties of sodiumdodecyl sulfate and dodecyltrimethylammonium bromide mixed surfactants and their interaction with dyes

Heliyon, 2019
The antagonistic as well as synergetic interaction for dodecyltrimethylammonium bromide (DTAB) and sodiumdodecyl sulfate (SDS) mixed surfactants by using surface tension are investigated on the basis of the results obtained earlier, the efficiency of ...
K.M. Sachin, Sameer A. Karpe, Man Singh, Ajaya Bhattarai   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Molecular interaction studies of binary systems comprising [C2mim] [BF4] with ethyl acetoacetate or benzaldehyde

Heliyon, 2019
In this work, new data for the binary mixtures containing 1-ethyl-3-methylimidazolium tetrafluoroborate ([C2mim] [BF4]) ionic liquid (IL) with benzaldehyde or ethyl acetoacetate were investigated under atmospheric pressure (p = 0.1 MPa) and at ...
Bakusele Kabane, Rajasekhar Chokkareddy, Gan G. Redhi   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

AN INTRODUCTION TO PHYSICAL CHEMISTRY. [PDF]

Journal of the American Chemical Society, 1900
n ...
openaire   +2 more sources