Results 141 to 150 of about 11,051,622 (301)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The Effects of Online Chemistry-Themed Design-Based STEM Education on Preservice Science Teachers’ STEM Awareness [PDF]

The study investigated the impact of Chemistry-Focused Online Science, Technology, Engineering, and Mathematics (STEM) teacher education on the awareness of STEM among preservice science teachers.
Burçin ACAR-ŞEŞEN, Emine ŞAHİN-TOPALCENGİZ, Şeşen, Burçin Acar, Topalcengiz, Emine Şahin, Acar-Sesen, Burcin   +4 more
core   +1 more source

Intervention for burnout among chemistry education undergraduates in Nigeria. [PDF]

J Int Med Res, 2020
Ezeudu FO, Nwoji IHN, Dave-Ugwu PO, Abaeme DO, Ikegbunna NR, Agugu CV, Muoneke MN, Alabi AO, Nwefuru BC.   +8 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Intervention for depression among chemistry education undergraduates in a Nigerian university. [PDF]

J Int Med Res, 2020
Ezeudu FO, Eya NM, Nwafor SC, Ogbonna CS.   +3 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Education in Chemistry

Chemistry instructors at a variety of levels may be interested in Education in Chemistry, the web version of a magazine for teachers published by the Royal Society of Chemistry.

core  

The Infiltration Education of Environmental Protection Consciousness on the Analysis Chemistry Teaching [PDF]

, 2018
Infiltrate environmental protection awareness into the teaching of analytical chemistry, and combine environmental education and analytical chemistry teaching organically.
Wang, Jing-Ping
core  

Removal of Heavy Metal Ion Using Polymer-Functionalized Activated Carbon: Aspects of Environmental Economic and Chemistry Education. [PDF]

J Anal Methods Chem, 2020
Ha HT, Huong NT, Dan LL, Tung ND, Trung VB, Minh TD.   +5 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source